Names & Taxonomy

Uniprot ID:
P45880
Entry Name:
VDAC2_HUMAN
Status:
reviewed
Protein Names:
Voltage-dependent anion-selective channel protein 2 (VDAC-2) (hVDAC2) (Outer mitochondrial membrane protein porin 2)
Gene Names:
VDAC2
Gene Names Primary:
VDAC2
Organism:
Homo sapiens (Human)

Structure

Length:
294
Sequence:
MATHGQTCARPMCIPPSYADLGKAARDIFNKGFGFGLVKLDVKTKSCSGVEFSTSGSSNTDTGKVTGTLETKYKWCEYGLTFTEKWNTDNTLGTEIAIEDQICQGLKLTFDTTFSPNTGKKSGKIKSSYKRECINLGCDVDFDFAGPAIHGSAVFGYEGWLAGYQMTFDSAKSKLTRNNFAVGYRTGDFQLHTNVNDGTEFGGSIYQKVCEDLDTSVNLAWTSGTNCTRFGIAAKYQLDPTASISAKVNNSSLIGVGYTQTLRPGVKLTLSALVDGKSINAGGHKVGLALELEA
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion outer membrane

Function

Function:
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective.
Cross Reference Drug Bank:
DB01375
Gene Ontology Go:
extracellular exosome
membrane raft
mitochondrial inner membrane
mitochondrial nucleoid
mitochondrial outer membrane
mitochondrion
myelin sheath
nucleus
pore complex
synaptic vesicle
nucleotide binding
porin activity
voltage-gated anion channel activity
anion transport
negative regulation of intrinsic apoptotic signaling pathway
negative regulation of protein polymerization
regulation of anion transmembrane transport
Gene Ontology Biological Process:
anion transport
negative regulation of intrinsic apoptotic signaling pathway
negative regulation of protein polymerization
regulation of anion transmembrane transport
Gene Ontology Molecular Function:
nucleotide binding
porin activity
voltage-gated anion channel activity
Gene Ontology Cellular Component:
extracellular exosome
membrane raft
mitochondrial inner membrane
mitochondrial nucleoid
mitochondrial outer membrane
mitochondrion
myelin sheath
nucleus
pore complex
synaptic vesicle
Keywords:
Acetylation
Alternative splicing
Complete proteome
Direct protein sequencing
Ion transport
Isopeptide bond
Membrane
Mitochondrion
Mitochondrion outer membrane
NAD
Nucleotide-binding
Polymorphism
Porin
Reference proteome
Transmembrane
Transmembrane beta strand
Transport
Ubl conjugation
Interacts With:
Q96A26

Publication

PubMed ID:
7685033 8420959 10501981 15164054 15489334 7539795 17081983 18088087 18691976 18669648 19413330 19608861 20068231 21269460 21406692 24275569 25621951 25944712