Names & Taxonomy
- Uniprot ID:
- P45880
- Entry Name:
- VDAC2_HUMAN
- Status:
- reviewed
- Protein Names:
- Voltage-dependent anion-selective channel protein 2 (VDAC-2) (hVDAC2) (Outer mitochondrial membrane protein porin 2)
- Gene Names:
- VDAC2
- Gene Names Primary:
- VDAC2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 294
- Sequence:
- MATHGQTCARPMCIPPSYADLGKAARDIFNKGFGFGLVKLDVKTKSCSGVEFSTSGSSNTDTGKVTGTLETKYKWCEYGLTFTEKWNTDNTLGTEIAIEDQICQGLKLTFDTTFSPNTGKKSGKIKSSYKRECINLGCDVDFDFAGPAIHGSAVFGYEGWLAGYQMTFDSAKSKLTRNNFAVGYRTGDFQLHTNVNDGTEFGGSIYQKVCEDLDTSVNLAWTSGTNCTRFGIAAKYQLDPTASISAKVNNSSLIGVGYTQTLRPGVKLTLSALVDGKSINAGGHKVGLALELEA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion outer membrane
Function
- Function:
- Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective.
- Cross Reference Drug Bank:
- DB01375
- Gene Ontology Go:
- extracellular exosome
membrane raft
mitochondrial inner membrane
mitochondrial nucleoid
mitochondrial outer membrane
mitochondrion
myelin sheath
nucleus
pore complex
synaptic vesicle
nucleotide binding
porin activity
voltage-gated anion channel activity
anion transport
negative regulation of intrinsic apoptotic signaling pathway
negative regulation of protein polymerization
regulation of anion transmembrane transport - Gene Ontology Biological Process:
- anion transport
negative regulation of intrinsic apoptotic signaling pathway
negative regulation of protein polymerization
regulation of anion transmembrane transport - Gene Ontology Molecular Function:
- nucleotide binding
porin activity
voltage-gated anion channel activity - Gene Ontology Cellular Component:
- extracellular exosome
membrane raft
mitochondrial inner membrane
mitochondrial nucleoid
mitochondrial outer membrane
mitochondrion
myelin sheath
nucleus
pore complex
synaptic vesicle - Keywords:
- Acetylation
Alternative splicing
Complete proteome
Direct protein sequencing
Ion transport
Isopeptide bond
Membrane
Mitochondrion
Mitochondrion outer membrane
NAD
Nucleotide-binding
Polymorphism
Porin
Reference proteome
Transmembrane
Transmembrane beta strand
Transport
Ubl conjugation - Interacts With:
- Q96A26