Names & Taxonomy
- Uniprot ID:
- P45452
- Entry Name:
- MMP13_HUMAN
- Status:
- reviewed
- Protein Names:
- Collagenase 3 (EC 3.4.24.-) (Matrix metalloproteinase-13) (MMP-13)
- Gene Names:
- MMP13
- Gene Names Primary:
- MMP13
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 471
- Sequence:
- MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space, extracellular matrix
Function
- Function:
- Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by TIMP1, TIMP2 and TIMP3. Inhibited by acetohydroxamic acid and other zinc chelators.
- Active Site:
- ACT_SITE 223 223
- Cross Reference Drug Bank:
- DB00786
- Gene Ontology Go:
- extracellular region
extracellular space
Golgi apparatus
intercellular canaliculus
lysosome
proteinaceous extracellular matrix
calcium ion binding
collagen binding
metalloendopeptidase activity
zinc ion binding
bone mineralization
bone morphogenesis
cellular protein metabolic process
cellular response to fluid shear stress
collagen catabolic process
embryonic hindlimb morphogenesis
endochondral ossification
estrous cycle
extracellular matrix disassembly
extracellular matrix organization
growth plate cartilage development
heart development
luteolysis
osteoblast differentiation
parturition
peptide catabolic process
positive regulation of pancreatic trypsinogen secretion
proteolysis
response to drug
response to estrogen
response to hypoxia
response to mechanical stimulus - Gene Ontology Biological Process:
- bone mineralization
bone morphogenesis
cellular protein metabolic process
cellular response to fluid shear stress
collagen catabolic process
embryonic hindlimb morphogenesis
endochondral ossification
estrous cycle
extracellular matrix disassembly
extracellular matrix organization
growth plate cartilage development
heart development
luteolysis
osteoblast differentiation
parturition
peptide catabolic process
positive regulation of pancreatic trypsinogen secretion
proteolysis
response to drug
response to estrogen
response to hypoxia
response to mechanical stimulus - Gene Ontology Molecular Function:
- calcium ion binding
collagen binding
metalloendopeptidase activity
zinc ion binding - Gene Ontology Cellular Component:
- extracellular region
extracellular space
Golgi apparatus
intercellular canaliculus
lysosome
proteinaceous extracellular matrix - Keywords:
- 3D-structure
Calcium
Collagen degradation
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Dwarfism
Extracellular matrix
Glycoprotein
Hydrolase
Metal-binding
Metalloprotease
Phosphoprotein
Polymorphism
Protease
Reference proteome
Repeat
Secreted
Signal
Zinc
Zymogen