Names & Taxonomy
- Uniprot ID:
- P45381
- Entry Name:
- ACY2_HUMAN
- Status:
- reviewed
- Protein Names:
- Aspartoacylase (EC 3.5.1.15) (Aminoacylase-2) (ACY-2)
- Gene Names:
- ASPA ACY2 ASP
- Gene Names Primary:
- ASPA
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 313
- Sequence:
- MTSCHIAEEHIQKVAIFGGTHGNELTGVFLVKHWLENGAEIQRTGLEVKPFITNPRAVKKCTRYIDCDLNRIFDLENLGKKMSEDLPYEVRRAQEINHLFGPKDSEDSYDIIFDLHNTTSNMGCTLILEDSRNNFLIQMFHYIKTSLAPLPCYVYLIEHPSLKYATTRSIAKYPVGIEVGPQPQGVLRADILDQMRKMIKHALDFIHHFNEGKEFPPCAIEVYKIIEKVDYPRDENGEIAAIIHPNLQDQDWKPLHPGDPMFLTLDGKTIPLGGDCTVYPVFVNEAAYYEKKEAFAKTTKLTLNAKSIRCCLH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Nucleus
Function
- Function:
- Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids.
- Catalytic Activity:
- N-acyl-L-aspartate + H(2)O = a carboxylate + L-aspartate.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Active Site:
- ACT_SITE 178 178
- Cross Reference Drug Bank:
- DB00128
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
nucleus
aminoacylase activity
aspartoacylase activity
hydrolase activity, acting on ester bonds
metal ion binding
aspartate catabolic process
cellular amino acid biosynthetic process
cellular nitrogen compound metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- aspartate catabolic process
cellular amino acid biosynthetic process
cellular nitrogen compound metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- aminoacylase activity
aspartoacylase activity
hydrolase activity, acting on ester bonds
metal ion binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
nucleus - Keywords:
- 3D-structure
Complete proteome
Cytoplasm
Disease mutation
Hydrolase
Leukodystrophy
Metal-binding
Nucleus
Reference proteome
Zinc - Interacts With:
- Q96HD9