Names & Taxonomy
- Uniprot ID:
- P43220
- Entry Name:
- GLP1R_HUMAN
- Status:
- reviewed
- Protein Names:
- Glucagon-like peptide 1 receptor (GLP-1 receptor) (GLP-1-R) (GLP-1R)
- Gene Names:
- GLP1R
- Gene Names Primary:
- GLP1R
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 463
- Sequence:
- MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
- Cross Reference Drug Bank:
- DB09043 DB09045 DB01276 DB00040 DB06655
- Gene Ontology Go:
- integral component of membrane
intracellular
plasma membrane
glucagon receptor activity
transmembrane signaling receptor activity
activation of adenylate cyclase activity
cAMP-mediated signaling
cell surface receptor signaling pathway
energy reserve metabolic process
learning or memory
positive regulation of blood pressure
positive regulation of cytosolic calcium ion concentration
regulation of heart contraction
regulation of insulin secretion
response to stress
small molecule metabolic process - Gene Ontology Biological Process:
- activation of adenylate cyclase activity
cAMP-mediated signaling
cell surface receptor signaling pathway
energy reserve metabolic process
learning or memory
positive regulation of blood pressure
positive regulation of cytosolic calcium ion concentration
regulation of heart contraction
regulation of insulin secretion
response to stress
small molecule metabolic process - Gene Ontology Molecular Function:
- glucagon receptor activity
transmembrane signaling receptor activity - Gene Ontology Cellular Component:
- integral component of membrane
intracellular
plasma membrane - Keywords:
- 3D-structure
ADP-ribosylation
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Signal
Transducer
Transmembrane
Transmembrane helix - Interacts With:
- P60409; P60410; P60411; Q7Z3S9