Names & Taxonomy
- Uniprot ID:
- P43155
- Entry Name:
- CACP_HUMAN
- Status:
- reviewed
- Protein Names:
- Carnitine O-acetyltransferase (Carnitine acetylase) (EC 2.3.1.7) (Carnitine acetyltransferase) (CAT) (CrAT)
- Gene Names:
- CRAT CAT1
- Gene Names Primary:
- CRAT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 626
- Sequence:
- MLAFAARTVVKPLGFLKPFSLMKASSRFKAHQDALPRLPVPPLQQSLDHYLKALQPIVSEEEWAHTKQLVDEFQASGGVGERLQKGLERRARKTENWLSEWWLKTAYLQYRQPVVIYSSPGVMLPKQDFVDLQGQLRFAAKLIEGVLDFKVMIDNETLPVEYLGGKPLCMNQYYQILSSCRVPGPKQDTVSNFSKTKKPPTHITVVHNYQFFELDVYHSDGTPLTADQIFVQLEKIWNSSLQTNKEPVGILTSNHRNSWAKAYNTLIKDKVNRDSVRSIQKSIFTVCLDATMPRVSEDVYRSHVAGQMLHGGGSRLNSGNRWFDKTLQFIVAEDGSCGLVYEHAAAEGPPIVTLLDYVIEYTKKPELVRSPLVPLPMPKKLRFNITPEIKSDIEKAKQNLSIMIQDLDITVMVFHHFGKDFPKSEKLSPDAFIQMALQLAYYRIYGQACATYESASLRMFHLGRTDTIRSASMDSLTFVKAMDDSSVTEHQKVELLRKAVQAHRGYTDRAIRGEAFDRHLLGLKLQAIEDLVSMPDIFMDTSYAIAMHFHLSTSQVPAKTDCVMFFGPVVPDGYGVCYNPMEAHINFSLSAYNSCAETNAARLAHYLEKALLDMRALLQSHPRAKL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum
Function
- Function:
- Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.
- Catalytic Activity:
- Acetyl-CoA + carnitine = CoA + O-acetylcarnitine.
- Active Site:
- ACT_SITE 343 343 Proton acceptor.
- Cross Reference Drug Bank:
- DB00583
- Gene Ontology Go:
- endoplasmic reticulum
mitochondrial inner membrane
mitochondrion
peroxisomal matrix
peroxisome
carnitine O-acetyltransferase activity
receptor binding
carnitine metabolic process, CoA-linked
cellular lipid metabolic process
fatty acid beta-oxidation using acyl-CoA oxidase
small molecule metabolic process
transport - Gene Ontology Biological Process:
- carnitine metabolic process, CoA-linked
cellular lipid metabolic process
fatty acid beta-oxidation using acyl-CoA oxidase
small molecule metabolic process
transport - Gene Ontology Molecular Function:
- carnitine O-acetyltransferase activity
receptor binding - Gene Ontology Cellular Component:
- endoplasmic reticulum
mitochondrial inner membrane
mitochondrion
peroxisomal matrix
peroxisome - Keywords:
- 3D-structure
Acetylation
Acyltransferase
Alternative splicing
Complete proteome
Direct protein sequencing
Endoplasmic reticulum
Fatty acid metabolism
Lipid metabolism
Membrane
Mitochondrion
Mitochondrion inner membrane
Peroxisome
Polymorphism
Reference proteome
Transferase
Transport