Names & Taxonomy

Uniprot ID:
P43155
Entry Name:
CACP_HUMAN
Status:
reviewed
Protein Names:
Carnitine O-acetyltransferase (Carnitine acetylase) (EC 2.3.1.7) (Carnitine acetyltransferase) (CAT) (CrAT)
Gene Names:
CRAT CAT1
Gene Names Primary:
CRAT
Organism:
Homo sapiens (Human)

Structure

Length:
626
Sequence:
MLAFAARTVVKPLGFLKPFSLMKASSRFKAHQDALPRLPVPPLQQSLDHYLKALQPIVSEEEWAHTKQLVDEFQASGGVGERLQKGLERRARKTENWLSEWWLKTAYLQYRQPVVIYSSPGVMLPKQDFVDLQGQLRFAAKLIEGVLDFKVMIDNETLPVEYLGGKPLCMNQYYQILSSCRVPGPKQDTVSNFSKTKKPPTHITVVHNYQFFELDVYHSDGTPLTADQIFVQLEKIWNSSLQTNKEPVGILTSNHRNSWAKAYNTLIKDKVNRDSVRSIQKSIFTVCLDATMPRVSEDVYRSHVAGQMLHGGGSRLNSGNRWFDKTLQFIVAEDGSCGLVYEHAAAEGPPIVTLLDYVIEYTKKPELVRSPLVPLPMPKKLRFNITPEIKSDIEKAKQNLSIMIQDLDITVMVFHHFGKDFPKSEKLSPDAFIQMALQLAYYRIYGQACATYESASLRMFHLGRTDTIRSASMDSLTFVKAMDDSSVTEHQKVELLRKAVQAHRGYTDRAIRGEAFDRHLLGLKLQAIEDLVSMPDIFMDTSYAIAMHFHLSTSQVPAKTDCVMFFGPVVPDGYGVCYNPMEAHINFSLSAYNSCAETNAARLAHYLEKALLDMRALLQSHPRAKL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum

Function

Function:
Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.
Catalytic Activity:
Acetyl-CoA + carnitine = CoA + O-acetylcarnitine.
Active Site:
ACT_SITE 343 343 Proton acceptor.
Cross Reference Drug Bank:
DB00583
Gene Ontology Go:
endoplasmic reticulum
mitochondrial inner membrane
mitochondrion
peroxisomal matrix
peroxisome
carnitine O-acetyltransferase activity
receptor binding
carnitine metabolic process, CoA-linked
cellular lipid metabolic process
fatty acid beta-oxidation using acyl-CoA oxidase
small molecule metabolic process
transport
Gene Ontology Biological Process:
carnitine metabolic process, CoA-linked
cellular lipid metabolic process
fatty acid beta-oxidation using acyl-CoA oxidase
small molecule metabolic process
transport
Gene Ontology Molecular Function:
carnitine O-acetyltransferase activity
receptor binding
Gene Ontology Cellular Component:
endoplasmic reticulum
mitochondrial inner membrane
mitochondrion
peroxisomal matrix
peroxisome
Keywords:
3D-structure
Acetylation
Acyltransferase
Alternative splicing
Complete proteome
Direct protein sequencing
Endoplasmic reticulum
Fatty acid metabolism
Lipid metabolism
Membrane
Mitochondrion
Mitochondrion inner membrane
Peroxisome
Polymorphism
Reference proteome
Transferase
Transport

Publication

PubMed ID:
15164053 15489334 7945262 7829107 19608861 24275569 25944712 12562770 15099582