Names & Taxonomy
- Uniprot ID:
- P43116
- Entry Name:
- PE2R2_HUMAN
- Status:
- reviewed
- Protein Names:
- Prostaglandin E2 receptor EP2 subtype (PGE receptor EP2 subtype) (PGE2 receptor EP2 subtype) (Prostanoid EP2 receptor)
- Gene Names:
- PTGER2
- Gene Names Primary:
- PTGER2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 358
- Sequence:
- MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.
- Cross Reference Drug Bank:
- DB00770 DB00917 DB00929
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
prostaglandin E receptor activity
adenylate cyclase-activating G-protein coupled receptor signaling pathway
cellular response to prostaglandin E stimulus
G-protein coupled receptor signaling pathway
regulation of cell proliferation
response to lipopolysaccharide
response to progesterone - Gene Ontology Biological Process:
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
cellular response to prostaglandin E stimulus
G-protein coupled receptor signaling pathway
regulation of cell proliferation
response to lipopolysaccharide
response to progesterone - Gene Ontology Molecular Function:
- prostaglandin E receptor activity
- Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix