Names & Taxonomy

Uniprot ID:
P43005
Entry Name:
EAA3_HUMAN
Status:
reviewed
Protein Names:
Excitatory amino acid transporter 3 (Excitatory amino-acid carrier 1) (Neuronal and epithelial glutamate transporter) (Sodium-dependent glutamate/aspartate transporter 3) (Solute carrier family 1 member 1)
Gene Names:
SLC1A1 EAAC1 EAAT3
Gene Names Primary:
SLC1A1
Organism:
Homo sapiens (Human)

Structure

Length:
524
Sequence:
MGKPARKGCEWKRFLKNNWVLLSTVAAVVLGITTGVLVREHSNLSTLEKFYFAFPGEILMRMLKLIILPLIISSMITGVAALDSNVSGKIGLRAVVYYFCTTLIAVILGIVLVVSIKPGVTQKVGEIARTGSTPEVSTVDAMLDLIRNMFPENLVQACFQQYKTKREEVKPPSDPEMNMTEESFTAVMTTAISKNKTKEYKIVGMYSDGINVLGLIVFCLVFGLVIGKMGEKGQILVDFFNALSDATMKIVQIIMCYMPLGILFLIAGKIIEVEDWEIFRKLGLYMATVLTGLAIHSIVILPLIYFIVVRKNPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLPVGATINMDGTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMVIVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQMDVSSEVNIVNPFALESTILDNEDSDTKKSYVNGGFAVDKSDTISFTQTSQF
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Transports L-glutamate, L- and D-aspartate and L-cystein (PubMed:21123949). Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity).
Cross Reference Drug Bank:
DB00128 DB00230
Gene Ontology Go:
apical plasma membrane
extracellular exosome
integral component of plasma membrane
membrane
plasma membrane
presynapse
cysteine transmembrane transporter activity
glutamate binding
glutamate:sodium symporter activity
L-glutamate transmembrane transporter activity
sodium:dicarboxylate symporter activity
cysteine transmembrane transport
cysteine transport
D-aspartate import
glutamate secretion
ion transport
L-glutamate import
L-glutamate transmembrane transport
neurotransmitter secretion
positive regulation of heart rate
protein homooligomerization
synaptic transmission
transmembrane transport
Gene Ontology Biological Process:
cysteine transmembrane transport
cysteine transport
D-aspartate import
glutamate secretion
ion transport
L-glutamate import
L-glutamate transmembrane transport
neurotransmitter secretion
positive regulation of heart rate
protein homooligomerization
synaptic transmission
transmembrane transport
Gene Ontology Molecular Function:
cysteine transmembrane transporter activity
glutamate:sodium symporter activity
glutamate binding
L-glutamate transmembrane transporter activity
sodium:dicarboxylate symporter activity
Gene Ontology Cellular Component:
apical plasma membrane
extracellular exosome
integral component of plasma membrane
membrane
plasma membrane
presynapse
Keywords:
Cell membrane
Complete proteome
Disease mutation
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Schizophrenia
Symport
Transmembrane
Transmembrane helix
Transport
Interacts With:
Q5T700; Q99942

Publication

PubMed ID:
7859077 7914198 7521911 11317217 15164053 15489334 21982423 23341099 21123949