Names & Taxonomy
- Uniprot ID:
- P43005
- Entry Name:
- EAA3_HUMAN
- Status:
- reviewed
- Protein Names:
- Excitatory amino acid transporter 3 (Excitatory amino-acid carrier 1) (Neuronal and epithelial glutamate transporter) (Sodium-dependent glutamate/aspartate transporter 3) (Solute carrier family 1 member 1)
- Gene Names:
- SLC1A1 EAAC1 EAAT3
- Gene Names Primary:
- SLC1A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 524
- Sequence:
- MGKPARKGCEWKRFLKNNWVLLSTVAAVVLGITTGVLVREHSNLSTLEKFYFAFPGEILMRMLKLIILPLIISSMITGVAALDSNVSGKIGLRAVVYYFCTTLIAVILGIVLVVSIKPGVTQKVGEIARTGSTPEVSTVDAMLDLIRNMFPENLVQACFQQYKTKREEVKPPSDPEMNMTEESFTAVMTTAISKNKTKEYKIVGMYSDGINVLGLIVFCLVFGLVIGKMGEKGQILVDFFNALSDATMKIVQIIMCYMPLGILFLIAGKIIEVEDWEIFRKLGLYMATVLTGLAIHSIVILPLIYFIVVRKNPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLPVGATINMDGTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMVIVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQMDVSSEVNIVNPFALESTILDNEDSDTKKSYVNGGFAVDKSDTISFTQTSQF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Transports L-glutamate, L- and D-aspartate and L-cystein (PubMed:21123949). Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity).
- Cross Reference Drug Bank:
- DB00128 DB00230
- Gene Ontology Go:
- apical plasma membrane
extracellular exosome
integral component of plasma membrane
membrane
plasma membrane
presynapse
cysteine transmembrane transporter activity
glutamate binding
glutamate:sodium symporter activity
L-glutamate transmembrane transporter activity
sodium:dicarboxylate symporter activity
cysteine transmembrane transport
cysteine transport
D-aspartate import
glutamate secretion
ion transport
L-glutamate import
L-glutamate transmembrane transport
neurotransmitter secretion
positive regulation of heart rate
protein homooligomerization
synaptic transmission
transmembrane transport - Gene Ontology Biological Process:
- cysteine transmembrane transport
cysteine transport
D-aspartate import
glutamate secretion
ion transport
L-glutamate import
L-glutamate transmembrane transport
neurotransmitter secretion
positive regulation of heart rate
protein homooligomerization
synaptic transmission
transmembrane transport - Gene Ontology Molecular Function:
- cysteine transmembrane transporter activity
glutamate:sodium symporter activity
glutamate binding
L-glutamate transmembrane transporter activity
sodium:dicarboxylate symporter activity - Gene Ontology Cellular Component:
- apical plasma membrane
extracellular exosome
integral component of plasma membrane
membrane
plasma membrane
presynapse - Keywords:
- Cell membrane
Complete proteome
Disease mutation
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Schizophrenia
Symport
Transmembrane
Transmembrane helix
Transport - Interacts With:
- Q5T700; Q99942