Names & Taxonomy
- Uniprot ID:
- P43003
- Entry Name:
- EAA1_HUMAN
- Status:
- reviewed
- Protein Names:
- Excitatory amino acid transporter 1 (Sodium-dependent glutamate/aspartate transporter 1) (GLAST-1) (Solute carrier family 1 member 3)
- Gene Names:
- SLC1A3 EAAT1 GLAST GLAST1
- Gene Names Primary:
- SLC1A3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 542
- Sequence:
- MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIVGTILGFTLRPYRMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASGKMGMRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKENMHREGKIVRVTAADAFLDLIRNMFPPNLVEACFKQFKTNYEKRSFKVPIQANETLVGAVINNVSEAMETLTRITEELVPVPGSVNGVNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPVGILFLIAGKIVEMEDMGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITALGTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFELNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSLGAGIVEHLSRHELKNRDVEMGNSVIEENEMKKPYQLIAQDNETEKPIDSETKM
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.
- Gene Ontology Go:
- basolateral plasma membrane
cell surface
dendritic spine
fibril
integral component of membrane
membrane
mitochondrial inner membrane
neuronal cell body
plasma membrane
presynapse
glutamate binding
high-affinity glutamate transmembrane transporter activity
L-glutamate transmembrane transporter activity
sodium:dicarboxylate symporter activity
auditory behavior
cell morphogenesis involved in neuron differentiation
cranial nerve development
D-aspartate import
gamma-aminobutyric acid biosynthetic process
glutamate biosynthetic process
glutamate secretion
ion transport
L-glutamate import
L-glutamate transmembrane transport
malate-aspartate shuttle
mitophagy in response to mitochondrial depolarization
neuromuscular process controlling balance
neurotransmitter secretion
neurotransmitter uptake
positive regulation of defense response to virus by host
positive regulation of synaptic transmission
response to antibiotic
response to drug
response to light stimulus
response to wounding
sensory perception of sound
synaptic transmission
transmembrane transport
xenophagy - Gene Ontology Biological Process:
- auditory behavior
cell morphogenesis involved in neuron differentiation
cranial nerve development
D-aspartate import
gamma-aminobutyric acid biosynthetic process
glutamate biosynthetic process
glutamate secretion
ion transport
L-glutamate import
L-glutamate transmembrane transport
malate-aspartate shuttle
mitophagy in response to mitochondrial depolarization
neuromuscular process controlling balance
neurotransmitter secretion
neurotransmitter uptake
positive regulation of defense response to virus by host
positive regulation of synaptic transmission
response to antibiotic
response to drug
response to light stimulus
response to wounding
sensory perception of sound
synaptic transmission
transmembrane transport
xenophagy - Gene Ontology Molecular Function:
- glutamate binding
high-affinity glutamate transmembrane transporter activity
L-glutamate transmembrane transporter activity
sodium:dicarboxylate symporter activity - Gene Ontology Cellular Component:
- basolateral plasma membrane
cell surface
dendritic spine
fibril
integral component of membrane
membrane
mitochondrial inner membrane
neuronal cell body
plasma membrane
presynapse - Keywords:
- Alternative splicing
Complete proteome
Disease mutation
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Symport
Transmembrane
Transmembrane helix
Transport