Names & Taxonomy
- Uniprot ID:
- P42262
- Entry Name:
- GRIA2_HUMAN
- Status:
- reviewed
- Protein Names:
- Glutamate receptor 2 (GluR-2) (AMPA-selective glutamate receptor 2) (GluR-B) (GluR-K2) (Glutamate receptor ionotropic, AMPA 2) (GluA2)
- Gene Names:
- GRIA2 GLUR2
- Gene Names Primary:
- GRIA2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 883
- Sequence:
- MQKIMHISVLLSPVLWGLIFGVSSNSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKVAKNAQNINPSSSQNSQNFATYKEGYNVYGIESVKI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
- Intramembrane:
- INTRAMEM 592 607 Helical; Pore-forming.
Function
- Function:
- Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
- Cross Reference Drug Bank:
- DB01351 DB01352 DB00237 DB00241 DB01353 DB00898 DB01354 DB01355 DB00849 DB00312 DB01174 DB00794 DB01346 DB00418 DB00306 DB00599
- Gene Ontology Go:
- AMPA glutamate receptor complex
cell junction
endocytic vesicle membrane
endoplasmic reticulum membrane
integral component of plasma membrane
plasma membrane
postsynaptic membrane
AMPA glutamate receptor activity
extracellular-glutamate-gated ion channel activity
ionotropic glutamate receptor activity
ionotropic glutamate receptor signaling pathway
signal transduction
synaptic transmission - Gene Ontology Biological Process:
- ionotropic glutamate receptor signaling pathway
signal transduction
synaptic transmission - Gene Ontology Molecular Function:
- AMPA glutamate receptor activity
extracellular-glutamate-gated ion channel activity
ionotropic glutamate receptor activity - Gene Ontology Cellular Component:
- AMPA glutamate receptor complex
cell junction
endocytic vesicle membrane
endoplasmic reticulum membrane
integral component of plasma membrane
plasma membrane
postsynaptic membrane - Keywords:
- 3D-structure
Alternative splicing
Cell junction
Cell membrane
Complete proteome
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Lipoprotein
Membrane
Palmitate
Phosphoprotein
Polymorphism
Postsynaptic cell membrane
RNA editing
Receptor
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport - Interacts With:
- P46459