Names & Taxonomy

Uniprot ID:
P41597
Entry Name:
CCR2_HUMAN
Status:
reviewed
Protein Names:
C-C chemokine receptor type 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (Monocyte chemoattractant protein 1 receptor) (MCP-1-R) (CD antigen CD192)
Gene Names:
CCR2 CMKBR2
Gene Names Primary:
CCR2
Organism:
Homo sapiens (Human)

Structure

Length:
374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection.
Gene Ontology Go:
cell surface
cytoplasm
cytosol
dendrite
endosome
integral component of membrane
integral component of plasma membrane
neuronal cell body
perikaryon
perinuclear region of cytoplasm
plasma membrane
C-C chemokine receptor activity
CCR2 chemokine receptor binding
chemokine receptor activity
protein homodimerization activity
aging
blood vessel remodeling
cellular calcium ion homeostasis
cellular defense response
cellular homeostasis
chemokine-mediated signaling pathway
chemotaxis
cytokine-mediated signaling pathway
defense response to bacterium
dendritic cell chemotaxis
fat cell differentiation
forebrain development
immune response
inflammatory response
inflammatory response to antigenic stimulus
innate immune response
JAK-STAT cascade
negative regulation of adenylate cyclase activity
negative regulation of angiogenesis
negative regulation of axon extension
negative regulation of cell migration
negative regulation of eosinophil degranulation
negative regulation of neural precursor cell proliferation
negative regulation of type 2 immune response
neuron death
positive regulation of alpha-beta T cell proliferation
positive regulation of apoptotic process by virus
positive regulation of astrocyte chemotaxis
positive regulation of CD8-positive, alpha-beta T cell extravasation
positive regulation of cell migration involved in sprouting angiogenesis
positive regulation of cytosolic calcium ion concentration
positive regulation of fever generation
positive regulation of gene expression
positive regulation of hematopoietic stem cell migration
positive regulation of immune complex clearance by monocytes and macrophages
positive regulation of inflammatory response
positive regulation of interferon-gamma production
positive regulation of interleukin-1 beta secretion
positive regulation of interleukin-2 production
positive regulation of interleukin-6 production
positive regulation of monocyte chemotaxis
positive regulation of monocyte extravasation
positive regulation of neuron differentiation
positive regulation of T cell activation
positive regulation of T cell chemotaxis
positive regulation of T-helper 1 type immune response
positive regulation of tumor necrosis factor biosynthetic process
regulation of vascular endothelial growth factor production
response to ionizing radiation
response to lipopolysaccharide
response to wounding
T-helper 17 cell chemotaxis
Gene Ontology Biological Process:
aging
blood vessel remodeling
cellular calcium ion homeostasis
cellular defense response
cellular homeostasis
chemokine-mediated signaling pathway
chemotaxis
cytokine-mediated signaling pathway
defense response to bacterium
dendritic cell chemotaxis
fat cell differentiation
forebrain development
immune response
inflammatory response
inflammatory response to antigenic stimulus
innate immune response
JAK-STAT cascade
negative regulation of adenylate cyclase activity
negative regulation of angiogenesis
negative regulation of axon extension
negative regulation of cell migration
negative regulation of eosinophil degranulation
negative regulation of neural precursor cell proliferation
negative regulation of type 2 immune response
neuron death
positive regulation of alpha-beta T cell proliferation
positive regulation of apoptotic process by virus
positive regulation of astrocyte chemotaxis
positive regulation of CD8-positive, alpha-beta T cell extravasation
positive regulation of cell migration involved in sprouting angiogenesis
positive regulation of cytosolic calcium ion concentration
positive regulation of fever generation
positive regulation of gene expression
positive regulation of hematopoietic stem cell migration
positive regulation of immune complex clearance by monocytes and macrophages
positive regulation of inflammatory response
positive regulation of interferon-gamma production
positive regulation of interleukin-1 beta secretion
positive regulation of interleukin-2 production
positive regulation of interleukin-6 production
positive regulation of monocyte chemotaxis
positive regulation of monocyte extravasation
positive regulation of neuron differentiation
positive regulation of T cell activation
positive regulation of T cell chemotaxis
positive regulation of T-helper 1 type immune response
positive regulation of tumor necrosis factor biosynthetic process
regulation of vascular endothelial growth factor production
response to ionizing radiation
response to lipopolysaccharide
response to wounding
T-helper 17 cell chemotaxis
Gene Ontology Molecular Function:
C-C chemokine receptor activity
CCR2 chemokine receptor binding
chemokine receptor activity
protein homodimerization activity
Gene Ontology Cellular Component:
cell surface
cytoplasm
cytosol
dendrite
endosome
integral component of membrane
integral component of plasma membrane
neuronal cell body
perikaryon
perinuclear region of cytoplasm
plasma membrane
Keywords:
3D-structure
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Host-virus interaction
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Sulfation
Transducer
Transmembrane
Transmembrane helix

Publication

PubMed ID:
8146186 8048929 8995400 14702039 16641997 15489334 9670957 9501202 9789057 11046064 18587271 23408426 9252328 9662369