Names & Taxonomy

Uniprot ID:
P41594
Entry Name:
GRM5_HUMAN
Status:
reviewed
Protein Names:
Metabotropic glutamate receptor 5 (mGluR5)
Gene Names:
GRM5 GPRC1E MGLUR5
Gene Names Primary:
GRM5
Organism:
Homo sapiens (Human)

Structure

Length:
1212
Sequence:
MVLLLILSVLLLKEDVRGSAQSSERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISSEEEEGLVRCVDGSSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAGEQSFDKLLKKLTSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQHRFQCRLEGFPQENSKYNKTCNSSLTLKTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMDDDEVWSKKSNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIREVYLICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTSTVVRMHVGDGKSSSAASRSSSLVNLWKRRGSSGETLRYKDRRLAQHKSEIECFTPKGSMGNGGRATMSSSNGKSVTWAQNEKSSRGQHLWQRLSIHINKKENPNQTAVIKPFPKSTESRGLGAGAGAGGSAGGVGATGGAGCAGAGPGGPESPDAGPKALYDVAEAEEHFPAPARPRSPSPISTLSHRAGSASRTDDDVPSLHSEPVARSSSSQGSLMEQISSVVTRFTANISELNSMMLSTAAPSPGVGAPLCSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQPAAGAQAAGDAARESPAAGPEAAAAKPDLEELVALTPPSPFRDSVDSGSTTPNSPVSESALCIPSSPKYDTLIIRDYTQSSSSL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity.
Cross Reference Drug Bank:
DB00659 DB06201
Gene Ontology Go:
cytoplasm
extracellular exosome
integral component of plasma membrane
neuron projection
plasma membrane
postsynaptic density
G-protein coupled receptor activity
glutamate receptor activity
cognition
G-protein coupled glutamate receptor signaling pathway
learning
locomotory behavior
phospholipase C-activating G-protein coupled glutamate receptor signaling pathway
protein kinase C-activating G-protein coupled receptor signaling pathway
regulation of long-term neuronal synaptic plasticity
synaptic transmission
Gene Ontology Biological Process:
cognition
G-protein coupled glutamate receptor signaling pathway
learning
locomotory behavior
phospholipase C-activating G-protein coupled glutamate receptor signaling pathway
protein kinase C-activating G-protein coupled receptor signaling pathway
regulation of long-term neuronal synaptic plasticity
synaptic transmission
Gene Ontology Molecular Function:
glutamate receptor activity
G-protein coupled receptor activity
Gene Ontology Cellular Component:
cytoplasm
extracellular exosome
integral component of plasma membrane
neuron projection
plasma membrane
postsynaptic density
Keywords:
3D-structure
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Phosphoprotein
Receptor
Reference proteome
Signal
Transducer
Transmembrane
Transmembrane helix

Publication

PubMed ID:
7908515 16554811 7688218