Names & Taxonomy
- Uniprot ID:
- P41594
- Entry Name:
- GRM5_HUMAN
- Status:
- reviewed
- Protein Names:
- Metabotropic glutamate receptor 5 (mGluR5)
- Gene Names:
- GRM5 GPRC1E MGLUR5
- Gene Names Primary:
- GRM5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1212
- Sequence:
- MVLLLILSVLLLKEDVRGSAQSSERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISSEEEEGLVRCVDGSSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAGEQSFDKLLKKLTSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQHRFQCRLEGFPQENSKYNKTCNSSLTLKTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMDDDEVWSKKSNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIREVYLICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTSTVVRMHVGDGKSSSAASRSSSLVNLWKRRGSSGETLRYKDRRLAQHKSEIECFTPKGSMGNGGRATMSSSNGKSVTWAQNEKSSRGQHLWQRLSIHINKKENPNQTAVIKPFPKSTESRGLGAGAGAGGSAGGVGATGGAGCAGAGPGGPESPDAGPKALYDVAEAEEHFPAPARPRSPSPISTLSHRAGSASRTDDDVPSLHSEPVARSSSSQGSLMEQISSVVTRFTANISELNSMMLSTAAPSPGVGAPLCSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQPAAGAQAAGDAARESPAAGPEAAAAKPDLEELVALTPPSPFRDSVDSGSTTPNSPVSESALCIPSSPKYDTLIIRDYTQSSSSL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity.
- Cross Reference Drug Bank:
- DB00659 DB06201
- Gene Ontology Go:
- cytoplasm
extracellular exosome
integral component of plasma membrane
neuron projection
plasma membrane
postsynaptic density
G-protein coupled receptor activity
glutamate receptor activity
cognition
G-protein coupled glutamate receptor signaling pathway
learning
locomotory behavior
phospholipase C-activating G-protein coupled glutamate receptor signaling pathway
protein kinase C-activating G-protein coupled receptor signaling pathway
regulation of long-term neuronal synaptic plasticity
synaptic transmission - Gene Ontology Biological Process:
- cognition
G-protein coupled glutamate receptor signaling pathway
learning
locomotory behavior
phospholipase C-activating G-protein coupled glutamate receptor signaling pathway
protein kinase C-activating G-protein coupled receptor signaling pathway
regulation of long-term neuronal synaptic plasticity
synaptic transmission - Gene Ontology Molecular Function:
- glutamate receptor activity
G-protein coupled receptor activity - Gene Ontology Cellular Component:
- cytoplasm
extracellular exosome
integral component of plasma membrane
neuron projection
plasma membrane
postsynaptic density - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Phosphoprotein
Receptor
Reference proteome
Signal
Transducer
Transmembrane
Transmembrane helix