Names & Taxonomy
- Uniprot ID:
- P41252
- Entry Name:
- SYIC_HUMAN
- Status:
- reviewed
- Protein Names:
- Isoleucine--tRNA ligase, cytoplasmic (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IRS) (IleRS)
- Gene Names:
- IARS
- Gene Names Primary:
- IARS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1262
- Sequence:
- MLQQVPENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKTLGIRGPEDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFESHQNYKDVQDPSVFVTFPLEEDETVSLVAWTTTPWTLPSNLAVCVNPEMQYVKIKDVARGRLLILMEARLSALYKLESDYEILERFPGAYLKGKKYRPLFDYFLKCKENGAFTVLVDNYVKEEEGTGVVHQAPYFGAEDYRVCMDFNIIRKDSLPVCPVDASGCFTTEVTDFAGQYVKDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDTPLIYKAVPSWFVRVENMVDQLLRNNDLCYWVPELVREKRFGNWLKDARDWTISRNRYWGTPIPLWVSDDFEEVVCIGSVAELEELSGAKISDLHRESVDHLTIPSRCGKGSLHRISEVFDCWFESGSMPYAQVHYPFENKREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINSPVVRAENLRFKEEGVRDVLKDVLLPWYNAYRFLIQNVLRLQKEEEIEFLYNENTVRESPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFVDILTNWYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLMAPYTPFLTELMYQNLKVLIDPVSVQDKDTLSIHYLMLPRVREELIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKEIVVIHQDPEALKDIKSLEKYIIEELNVRKVTLSTDKNKYGIRLRAEPDHMVLGKRLKGAFKAVMTSIKQLSSEELEQFQKTGTIVVEGHELHDEDIRLMYTFDQATGGTAQFEAHSDAQALVLLDVTPDQSMVDEGMAREVINRIQKLRKKCNLVPTDEITVYYKAKSEGTYLNSVIESHTEFIFTTIKAPLKPYPVSPSDKVLIQEKTQLKGSELEITLTRGSSLPGPACAYVNLNICANGSEQGGVLLLENPKGDNRLDLLKLKSVVTSIFGVKNTELAVFHDETEIQNQTDLLSLSGKTLCVTAGSAPSLINSSSTLLCQYINLQLLNAKPQECLMGTVGTLLLENPLGQNGLTHQGLLYEAAKVFGLRSRKLKLFLNETQTQEITEDIPVKTLNMKTVYVSVLPTTADF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Catalytic Activity:
- ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile).
- Cross Reference Drug Bank:
- DB00167
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
membrane
nucleoplasm
aminoacyl-tRNA editing activity
ATP binding
GTPase binding
isoleucine-tRNA ligase activity
cellular nitrogen compound metabolic process
gene expression
isoleucyl-tRNA aminoacylation
osteoblast differentiation
selenium compound metabolic process
small molecule metabolic process
tRNA aminoacylation for protein translation - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
gene expression
isoleucyl-tRNA aminoacylation
osteoblast differentiation
selenium compound metabolic process
small molecule metabolic process
tRNA aminoacylation for protein translation - Gene Ontology Molecular Function:
- aminoacyl-tRNA editing activity
ATP binding
GTPase binding
isoleucine-tRNA ligase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
membrane
nucleoplasm - Keywords:
- ATP-binding
Acetylation
Aminoacyl-tRNA synthetase
Complete proteome
Cytoplasm
Direct protein sequencing
Ligase
Nucleotide-binding
Phosphoprotein
Polymorphism
Protein biosynthesis
Reference proteome - Interacts With:
- P07814