Names & Taxonomy
- Uniprot ID:
- P41235
- Entry Name:
- HNF4A_HUMAN
- Status:
- reviewed
- Protein Names:
- Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4)
- Gene Names:
- HNF4A HNF4 NR2A1 TCF14
- Gene Names Primary:
- HNF4A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 474
- Sequence:
- MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus.
Function
- Function:
- Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1-antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1-alpha. May be essential for development of the liver, kidney and intestine.
- Gene Ontology Go:
- cytoplasm
nucleoplasm
nucleus
transcription factor complex
DNA binding
fatty acid binding
fatty-acyl-CoA binding
palmitoyl-CoA hydrolase activity
protein homodimerization activity
receptor binding
RNA polymerase II activating transcription factor binding
RNA polymerase II core promoter sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
steroid hormone receptor activity
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription factor activity, sequence-specific DNA binding
transcription regulatory region DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
zinc ion binding
acyl-CoA metabolic process
blood coagulation
cell differentiation
cell-cell junction organization
endocrine pancreas development
establishment of tissue polarity
gene expression
glucose homeostasis
lipid homeostasis
lipid metabolic process
negative regulation of activation of JAK2 kinase activity
negative regulation of cell growth
negative regulation of cell proliferation
negative regulation of mitotic cell cycle
negative regulation of protein import into nucleus, translocation
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of tyrosine phosphorylation of Stat5 protein
ornithine metabolic process
phospholipid homeostasis
positive regulation of cholesterol homeostasis
positive regulation of fatty acid biosynthetic process
positive regulation of gluconeogenesis
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
regulation of gastrulation
regulation of growth hormone receptor signaling pathway
regulation of insulin secretion
regulation of lipid metabolic process
regulation of microvillus assembly
regulation of transcription from RNA polymerase II promoter
response to cAMP
response to drug
response to glucose
sex differentiation
signal transduction involved in regulation of gene expression
SMAD protein signal transduction
transcription initiation from RNA polymerase II promoter
triglyceride homeostasis
xenobiotic metabolic process - Gene Ontology Biological Process:
- acyl-CoA metabolic process
blood coagulation
cell-cell junction organization
cell differentiation
endocrine pancreas development
establishment of tissue polarity
gene expression
glucose homeostasis
lipid homeostasis
lipid metabolic process
negative regulation of activation of JAK2 kinase activity
negative regulation of cell growth
negative regulation of cell proliferation
negative regulation of mitotic cell cycle
negative regulation of protein import into nucleus, translocation
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of tyrosine phosphorylation of Stat5 protein
ornithine metabolic process
phospholipid homeostasis
positive regulation of cholesterol homeostasis
positive regulation of fatty acid biosynthetic process
positive regulation of gluconeogenesis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of gastrulation
regulation of growth hormone receptor signaling pathway
regulation of insulin secretion
regulation of lipid metabolic process
regulation of microvillus assembly
regulation of transcription from RNA polymerase II promoter
response to cAMP
response to drug
response to glucose
sex differentiation
signal transduction involved in regulation of gene expression
SMAD protein signal transduction
transcription initiation from RNA polymerase II promoter
triglyceride homeostasis
xenobiotic metabolic process - Gene Ontology Molecular Function:
- DNA binding
fatty acid binding
fatty-acyl-CoA binding
palmitoyl-CoA hydrolase activity
protein homodimerization activity
receptor binding
RNA polymerase II activating transcription factor binding
RNA polymerase II core promoter sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
steroid hormone receptor activity
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription factor activity, sequence-specific DNA binding
transcription regulatory region DNA binding
zinc ion binding - Gene Ontology Cellular Component:
- cytoplasm
nucleoplasm
nucleus
transcription factor complex - Keywords:
- 3D-structure
Acetylation
Alternative promoter usage
Alternative splicing
Complete proteome
DNA-binding
Diabetes mellitus
Disease mutation
Isopeptide bond
Metal-binding
Nucleus
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Transcription
Transcription regulation
Ubl conjugation
Zinc
Zinc-finger - Interacts With:
- Q99967; A8MYZ6; P04150; Q9UBK2; Q92786; P23246; Q12772