Names & Taxonomy

Uniprot ID:
P41221
Entry Name:
WNT5A_HUMAN
Status:
reviewed
Protein Names:
Protein Wnt-5a
Gene Names:
WNT5A
Gene Names Primary:
WNT5A
Organism:
Homo sapiens (Human)

Structure

Length:
380
Sequence:
MKKSIGILSPGVALGMAGSAMSSKFFLVALAIFFSFAQVVIEANSWWSLGMNNPVQMSEVYIIGAQPLCSQLAGLSQGQKKLCHLYQDHMQYIGEGAKTGIKECQYQFRHRRWNCSTVDNTSVFGRVMQIGSRETAFTYAVSAAGVVNAMSRACREGELSTCGCSRAARPKDLPRDWLWGGCGDNIDYGYRFAKEFVDARERERIHAKGSYESARILMNLHNNEAGRRTVYNLADVACKCHGVSGSCSLKTCWLQLADFRKVGDALKEKYDSAAAMRLNSRGKLVQVNSRFNSPTTQDLVYIDPSPDYCVRNESTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDQFKTVQTERCHCKFHWCCYVKCKKCTEIVDQFVCK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted, extracellular space, extracellular matrix.

Function

Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.
Gene Ontology Go:
cell surface
clathrin-coated endocytic vesicle membrane
endocytic vesicle membrane
endoplasmic reticulum lumen
extracellular exosome
extracellular region
extracellular space
Golgi lumen
plasma membrane
proteinaceous extracellular matrix
chemoattractant activity involved in axon guidance
frizzled binding
receptor agonist activity
receptor tyrosine kinase-like orphan receptor binding
transcription factor activity, sequence-specific DNA binding
transcription regulatory region DNA binding
activation of GTPase activity
activation of JUN kinase activity
activation of MAPK activity
activation of protein kinase B activity
anterior/posterior axis specification, embryo
axon guidance
canonical Wnt signaling pathway
cartilage development
cell fate commitment
cellular protein localization
cellular response to calcium ion
cellular response to interferon-gamma
cellular response to lipopolysaccharide
cellular response to retinoic acid
cellular response to transforming growth factor beta stimulus
cervix development
chemoattraction of serotonergic neuron axon
chemorepulsion of dopaminergic neuron axon
cochlea morphogenesis
convergent extension involved in axis elongation
convergent extension involved in organogenesis
embryonic digit morphogenesis
embryonic skeletal system development
epithelial cell proliferation involved in mammary gland duct elongation
epithelial to mesenchymal transition
establishment of epithelial cell apical/basal polarity
establishment of planar polarity
estrous cycle
excitatory synapse assembly
face development
genitalia development
heart looping
hematopoietic stem cell proliferation
hindgut morphogenesis
hypophysis morphogenesis
inhibitory synapse assembly
keratinocyte differentiation
lateral sprouting involved in mammary gland duct morphogenesis
lens development in camera-type eye
lung alveolus development
male gonad development
mammary gland branching involved in thelarche
melanocyte proliferation
mesenchymal-epithelial cell signaling
mesodermal to mesenchymal transition involved in gastrulation
midgut development
negative regulation of apoptotic process
negative regulation of axon extension involved in axon guidance
negative regulation of BMP signaling pathway
negative regulation of canonical Wnt signaling pathway
negative regulation of cell proliferation in midbrain
negative regulation of epithelial cell proliferation
negative regulation of fat cell differentiation
negative regulation of fibroblast growth factor receptor signaling pathway
negative regulation of melanin biosynthetic process
negative regulation of mesenchymal cell proliferation
negative regulation of prostatic bud formation
negative regulation of synapse assembly
negative regulation of transcription, DNA-templated
neuron differentiation
non-canonical Wnt signaling pathway
non-canonical Wnt signaling pathway via JNK cascade
notochord morphogenesis
olfactory bulb interneuron development
optic cup formation involved in camera-type eye development
palate development
paraxial mesoderm formation
planar cell polarity pathway involved in axis elongation
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
planar cell polarity pathway involved in cardiac right atrium morphogenesis
planar cell polarity pathway involved in gastrula mediolateral intercalation
planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation
planar cell polarity pathway involved in neural tube closure
planar cell polarity pathway involved in outflow tract morphogenesis
planar cell polarity pathway involved in pericardium morphogenesis
planar cell polarity pathway involved in ventricular septum morphogenesis
positive regulation of angiogenesis
positive regulation of cartilage development
positive regulation of cell-cell adhesion mediated by cadherin
positive regulation of cGMP metabolic process
positive regulation of chemokine biosynthetic process
positive regulation of cytokine secretion involved in immune response
positive regulation of endocytosis
positive regulation of endothelial cell migration
positive regulation of endothelial cell proliferation
positive regulation of fibroblast proliferation
positive regulation of inflammatory response
positive regulation of interferon-gamma production
positive regulation of interleukin-1 beta secretion
positive regulation of interleukin-6 production
positive regulation of interleukin-8 secretion
positive regulation of macrophage activation
positive regulation of macrophage cytokine production
positive regulation of meiotic nuclear division
positive regulation of mesenchymal cell proliferation
positive regulation of neuron projection development
positive regulation of NF-kappaB transcription factor activity
positive regulation of non-canonical Wnt signaling pathway
positive regulation of ossification
positive regulation of peptidyl-serine phosphorylation
positive regulation of peptidyl-threonine phosphorylation
positive regulation of protein binding
positive regulation of protein catabolic process
positive regulation of protein kinase C activity
positive regulation of protein kinase C signaling
positive regulation of protein localization to synapse
positive regulation of response to cytokine stimulus
positive regulation of T cell chemotaxis
positive regulation of thymocyte apoptotic process
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
positive regulation of type I interferon-mediated signaling pathway
post-anal tail morphogenesis
primitive streak formation
prostate gland development
regulation of branching involved in mammary gland duct morphogenesis
regulation of cellular protein localization
response to estradiol
response to glucocorticoid
response to hyperoxia
response to organic substance
response to testosterone
somitogenesis
synapse assembly
type B pancreatic cell development
urinary bladder development
uterus development
vagina development
Wnt signaling pathway
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
Wnt signaling pathway, calcium modulating pathway
Wnt signaling pathway, planar cell polarity pathway
wound healing
Gene Ontology Biological Process:
activation of GTPase activity
activation of JUN kinase activity
activation of MAPK activity
activation of protein kinase B activity
anterior/posterior axis specification, embryo
axon guidance
canonical Wnt signaling pathway
cartilage development
cell fate commitment
cellular protein localization
cellular response to calcium ion
cellular response to interferon-gamma
cellular response to lipopolysaccharide
cellular response to retinoic acid
cellular response to transforming growth factor beta stimulus
cervix development
chemoattraction of serotonergic neuron axon
chemorepulsion of dopaminergic neuron axon
cochlea morphogenesis
convergent extension involved in axis elongation
convergent extension involved in organogenesis
embryonic digit morphogenesis
embryonic skeletal system development
epithelial cell proliferation involved in mammary gland duct elongation
epithelial to mesenchymal transition
establishment of epithelial cell apical/basal polarity
establishment of planar polarity
estrous cycle
excitatory synapse assembly
face development
genitalia development
heart looping
hematopoietic stem cell proliferation
hindgut morphogenesis
hypophysis morphogenesis
inhibitory synapse assembly
keratinocyte differentiation
lateral sprouting involved in mammary gland duct morphogenesis
lens development in camera-type eye
lung alveolus development
male gonad development
mammary gland branching involved in thelarche
melanocyte proliferation
mesenchymal-epithelial cell signaling
mesodermal to mesenchymal transition involved in gastrulation
midgut development
negative regulation of apoptotic process
negative regulation of axon extension involved in axon guidance
negative regulation of BMP signaling pathway
negative regulation of canonical Wnt signaling pathway
negative regulation of cell proliferation in midbrain
negative regulation of epithelial cell proliferation
negative regulation of fat cell differentiation
negative regulation of fibroblast growth factor receptor signaling pathway
negative regulation of melanin biosynthetic process
negative regulation of mesenchymal cell proliferation
negative regulation of prostatic bud formation
negative regulation of synapse assembly
negative regulation of transcription, DNA-templated
neuron differentiation
non-canonical Wnt signaling pathway
non-canonical Wnt signaling pathway via JNK cascade
notochord morphogenesis
olfactory bulb interneuron development
optic cup formation involved in camera-type eye development
palate development
paraxial mesoderm formation
planar cell polarity pathway involved in axis elongation
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
planar cell polarity pathway involved in cardiac right atrium morphogenesis
planar cell polarity pathway involved in gastrula mediolateral intercalation
planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation
planar cell polarity pathway involved in neural tube closure
planar cell polarity pathway involved in outflow tract morphogenesis
planar cell polarity pathway involved in pericardium morphogenesis
planar cell polarity pathway involved in ventricular septum morphogenesis
positive regulation of angiogenesis
positive regulation of cartilage development
positive regulation of cell-cell adhesion mediated by cadherin
positive regulation of cGMP metabolic process
positive regulation of chemokine biosynthetic process
positive regulation of cytokine secretion involved in immune response
positive regulation of endocytosis
positive regulation of endothelial cell migration
positive regulation of endothelial cell proliferation
positive regulation of fibroblast proliferation
positive regulation of inflammatory response
positive regulation of interferon-gamma production
positive regulation of interleukin-1 beta secretion
positive regulation of interleukin-6 production
positive regulation of interleukin-8 secretion
positive regulation of macrophage activation
positive regulation of macrophage cytokine production
positive regulation of meiotic nuclear division
positive regulation of mesenchymal cell proliferation
positive regulation of neuron projection development
positive regulation of NF-kappaB transcription factor activity
positive regulation of non-canonical Wnt signaling pathway
positive regulation of ossification
positive regulation of peptidyl-serine phosphorylation
positive regulation of peptidyl-threonine phosphorylation
positive regulation of protein binding
positive regulation of protein catabolic process
positive regulation of protein kinase C activity
positive regulation of protein kinase C signaling
positive regulation of protein localization to synapse
positive regulation of response to cytokine stimulus
positive regulation of T cell chemotaxis
positive regulation of thymocyte apoptotic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of type I interferon-mediated signaling pathway
post-anal tail morphogenesis
primitive streak formation
prostate gland development
regulation of branching involved in mammary gland duct morphogenesis
regulation of cellular protein localization
response to estradiol
response to glucocorticoid
response to hyperoxia
response to organic substance
response to testosterone
somitogenesis
synapse assembly
type B pancreatic cell development
urinary bladder development
uterus development
vagina development
Wnt signaling pathway
Wnt signaling pathway, calcium modulating pathway
Wnt signaling pathway, planar cell polarity pathway
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
wound healing
Gene Ontology Molecular Function:
chemoattractant activity involved in axon guidance
frizzled binding
receptor agonist activity
receptor tyrosine kinase-like orphan receptor binding
transcription factor activity, sequence-specific DNA binding
transcription regulatory region DNA binding
Gene Ontology Cellular Component:
cell surface
clathrin-coated endocytic vesicle membrane
endocytic vesicle membrane
endoplasmic reticulum lumen
extracellular exosome
extracellular region
extracellular space
Golgi lumen
plasma membrane
proteinaceous extracellular matrix
Keywords:
Alternative splicing
Chondrogenesis
Complete proteome
Developmental protein
Differentiation
Disease mutation
Disulfide bond
Dwarfism
Extracellular matrix
Glycoprotein
Lipoprotein
Reference proteome
Secreted
Signal
Wnt signaling pathway
Interacts With:
Q9Y5W5

Publication

PubMed ID:
8288227 14702039 15489334 15735754 17426020 19918918