Names & Taxonomy
- Uniprot ID:
- P41145
- Entry Name:
- OPRK_HUMAN
- Status:
- reviewed
- Protein Names:
- Kappa-type opioid receptor (K-OR-1) (KOR-1)
- Gene Names:
- OPRK1 OPRK
- Gene Names Primary:
- OPRK1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 380
- Sequence:
- MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
- Cross Reference Drug Bank:
- DB06274 DB00321 DB00921 DB00611 DB00318 DB00514 DB00647 DB01209 DB09272 DB00813 DB01452 DB00327 DB01221 DB06738 DB00854 DB00836 DB00825 DB06800 DB06148 DB00370 DB00295 DB00844 DB01183 DB00704 DB00497 DB00652 DB00454 DB00396 DB00899 DB00708 DB06204 DB00193
- Gene Ontology Go:
- axon terminus
dendrite
integral component of membrane
integral component of plasma membrane
neuron projection
perikaryon
plasma membrane
synapse
dynorphin receptor activity
neuropeptide binding
opioid receptor activity
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting opioid receptor signaling pathway
behavior
behavioral response to cocaine
cellular response to lipopolysaccharide
conditioned place preference
defense response to virus
eating behavior
estrous cycle
immune response
locomotory behavior
maternal behavior
negative regulation of luteinizing hormone secretion
neuropeptide signaling pathway
opioid receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of dopamine secretion
positive regulation of locomotion
positive regulation of p38MAPK cascade
positive regulation of potassium ion transmembrane transport
regulation of aerobic respiration
regulation of energy homeostasis
regulation of saliva secretion
regulation of sensory perception of pain
response to acrylamide
response to estrogen
response to ethanol
response to insulin
response to morphine
response to radiation
sensory perception
sensory perception of pain
sensory perception of temperature stimulus
synaptic transmission - Gene Ontology Biological Process:
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting opioid receptor signaling pathway
behavior
behavioral response to cocaine
cellular response to lipopolysaccharide
conditioned place preference
defense response to virus
eating behavior
estrous cycle
immune response
locomotory behavior
maternal behavior
negative regulation of luteinizing hormone secretion
neuropeptide signaling pathway
opioid receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of dopamine secretion
positive regulation of locomotion
positive regulation of p38MAPK cascade
positive regulation of potassium ion transmembrane transport
regulation of aerobic respiration
regulation of energy homeostasis
regulation of saliva secretion
regulation of sensory perception of pain
response to acrylamide
response to estrogen
response to ethanol
response to insulin
response to morphine
response to radiation
sensory perception
sensory perception of pain
sensory perception of temperature stimulus
synaptic transmission - Gene Ontology Molecular Function:
- dynorphin receptor activity
neuropeptide binding
opioid receptor activity - Gene Ontology Cellular Component:
- axon terminus
dendrite
integral component of membrane
integral component of plasma membrane
neuron projection
perikaryon
plasma membrane
synapse - Keywords:
- 3D-structure
Alternative splicing
Behavior
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Palmitate
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix - Interacts With:
- Q9H0R8