Names & Taxonomy

Uniprot ID:
P41091
Entry Name:
IF2G_HUMAN
Status:
reviewed
Protein Names:
Eukaryotic translation initiation factor 2 subunit 3 (Eukaryotic translation initiation factor 2 subunit gamma X) (eIF-2-gamma X) (eIF-2gX)
Gene Names:
EIF2S3 EIF2G
Gene Names Primary:
EIF2S3
Organism:
Homo sapiens (Human)

Structure

Length:
472
Sequence:
MAGGEAGVTLGQPHLSRQDLTTLDVTKLTPLSHEVISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIALSRRVEKHWRLIGWGQIRRGVTIKPTVDDD
Proteomes:
UP000005640

Function

Function:
As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (By similarity). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity).
Gene Ontology Go:
cytoplasm
cytosol
extracellular exosome
GTP binding
GTPase activity
translation factor activity, RNA binding
translation initiation factor activity
cellular protein metabolic process
formation of translation preinitiation complex
gene expression
translation
translational initiation
transmembrane transport
Gene Ontology Biological Process:
cellular protein metabolic process
formation of translation preinitiation complex
gene expression
translation
translational initiation
transmembrane transport
Gene Ontology Molecular Function:
GTPase activity
GTP binding
translation factor activity, RNA binding
translation initiation factor activity
Gene Ontology Cellular Component:
cytoplasm
cytosol
extracellular exosome
Keywords:
Acetylation
Complete proteome
Direct protein sequencing
GTP-binding
Initiation factor
Nucleotide-binding
Phosphoprotein
Polymorphism
Protein biosynthesis
Reference proteome
Interacts With:
P05198; P20042

Publication

PubMed ID:
8106381 14702039 19054851 15489334 12665801 9736774 21269460 25944712