Names & Taxonomy
- Uniprot ID:
- P39900
- Entry Name:
- MMP12_HUMAN
- Status:
- reviewed
- Protein Names:
- Macrophage metalloelastase (MME) (EC 3.4.24.65) (Macrophage elastase) (ME) (hME) (Matrix metalloproteinase-12) (MMP-12)
- Gene Names:
- MMP12 HME
- Gene Names Primary:
- MMP12
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 470
- Sequence:
- MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLMKEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFFFKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRPEPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITKNFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space, extracellular matrix
Function
- Function:
- May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
- Catalytic Activity:
- Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in the B chain of insulin.
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; ; Note=Binds 4 Ca(2+) ions per subunit.;; COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; ; Note=Binds 2 Zn(2+) ions per subunit.;
- Active Site:
- ACT_SITE 219 219
- Cross Reference Drug Bank:
- DB00551 DB00786
- Gene Ontology Go:
- extracellular region
proteinaceous extracellular matrix
calcium ion binding
endopeptidase activity
metalloendopeptidase activity
zinc ion binding
collagen catabolic process
extracellular matrix disassembly
extracellular matrix organization
positive regulation of epithelial cell proliferation involved in wound healing
proteolysis
response to drug
response to organic cyclic compound
wound healing, spreading of epidermal cells - Gene Ontology Biological Process:
- collagen catabolic process
extracellular matrix disassembly
extracellular matrix organization
positive regulation of epithelial cell proliferation involved in wound healing
proteolysis
response to drug
response to organic cyclic compound
wound healing, spreading of epidermal cells - Gene Ontology Molecular Function:
- calcium ion binding
endopeptidase activity
metalloendopeptidase activity
zinc ion binding - Gene Ontology Cellular Component:
- extracellular region
proteinaceous extracellular matrix - Keywords:
- 3D-structure
Calcium
Complete proteome
Disulfide bond
Extracellular matrix
Glycoprotein
Hydrolase
Metal-binding
Metalloprotease
Polymorphism
Protease
Reference proteome
Repeat
Secreted
Signal
Zinc
Zymogen