Names & Taxonomy
- Uniprot ID:
- P39086
- Entry Name:
- GRIK1_HUMAN
- Status:
- reviewed
- Protein Names:
- Glutamate receptor ionotropic, kainate 1 (GluK1) (Excitatory amino acid receptor 3) (EAA3) (Glutamate receptor 5) (GluR-5) (GluR5)
- Gene Names:
- GRIK1 GLUR5
- Gene Names Primary:
- GRIK1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 918
- Sequence:
- MEHGTLLAQPGLWTRDTSWALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNNDIEQAFCFFYGLQCKQTHPTNSTSGTTLSTDLECGKLIREERGIRKQSSVHTV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
Function
- Function:
- Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.
- Cross Reference Drug Bank:
- DB00273
- Gene Ontology Go:
- cell junction
integral component of plasma membrane
plasma membrane
postsynaptic membrane
extracellular-glutamate-gated ion channel activity
kainate selective glutamate receptor activity
central nervous system development
glutamate receptor signaling pathway
ionotropic glutamate receptor signaling pathway
nervous system development
regulation of synaptic transmission, glutamatergic
synaptic transmission
transport - Gene Ontology Biological Process:
- central nervous system development
glutamate receptor signaling pathway
ionotropic glutamate receptor signaling pathway
nervous system development
regulation of synaptic transmission, glutamatergic
synaptic transmission
transport - Gene Ontology Molecular Function:
- extracellular-glutamate-gated ion channel activity
kainate selective glutamate receptor activity - Gene Ontology Cellular Component:
- cell junction
integral component of plasma membrane
plasma membrane
postsynaptic membrane - Keywords:
- 3D-structure
Alternative splicing
Cell junction
Cell membrane
Complete proteome
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Phosphoprotein
Polymorphism
Postsynaptic cell membrane
RNA editing
Receptor
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport