Names & Taxonomy
- Uniprot ID:
- P38484
- Entry Name:
- INGR2_HUMAN
- Status:
- reviewed
- Protein Names:
- Interferon gamma receptor 2 (IFN-gamma receptor 2) (IFN-gamma-R2) (Interferon gamma receptor accessory factor 1) (AF-1) (Interferon gamma transducer 1)
- Gene Names:
- IFNGR2 IFNGT1
- Gene Names Primary:
- IFNGR2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 337
- Sequence:
- MRPTLLWSLLLLLGVFAAAAAAPPDPLSQLPAPQHPKIRLYNAEQVLSWEPVALSNSTRPVVYQVQFKYTDSKWFTADIMSIGVNCTQITATECDFTAASPSAGFPMDFNVTLRLRAELGALHSAWVTMPWFQHYRNVTVGPPENIEVTPGEGSLIIRFSSPFDIADTSTAFFCYYVHYWEKGGIQQVKGPFRSNSISLDNLKPSRVYCLQVQAQLLWNKSNIFRVGHLSNISCYETMADASTELQQVILISVGTFSLLSVLAGACFFLVLKYRGLIKYWFHTPPSIPLQIEEYLKDPTQPILEALDKDSSPKDDVWDSVSIISFPEKEQEDVLQTL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:8124716, PubMed:7673114,PubMed:7615558). Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:8124716, PubMed:7673114, PubMed:15356148). Required for signal transduction in contrast to other receptor subunit responsible for ligand binding (PubMed:7673114).
- Cross Reference Drug Bank:
- DB00033
- Gene Ontology Go:
- cytoplasmic vesicle membrane
endoplasmic reticulum
endoplasmic reticulum membrane
Golgi membrane
integral component of plasma membrane
plasma membrane
interferon-gamma receptor activity
cell surface receptor signaling pathway
cytokine-mediated signaling pathway
interferon-gamma-mediated signaling pathway
regulation of interferon-gamma-mediated signaling pathway
response to virus - Gene Ontology Biological Process:
- cell surface receptor signaling pathway
cytokine-mediated signaling pathway
interferon-gamma-mediated signaling pathway
regulation of interferon-gamma-mediated signaling pathway
response to virus - Gene Ontology Molecular Function:
- interferon-gamma receptor activity
- Gene Ontology Cellular Component:
- cytoplasmic vesicle membrane
endoplasmic reticulum
endoplasmic reticulum membrane
Golgi membrane
integral component of plasma membrane
plasma membrane - Keywords:
- Cell membrane
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Disease mutation
Endoplasmic reticulum
Glycoprotein
Golgi apparatus
Membrane
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix