Names & Taxonomy
- Uniprot ID:
- P38435
- Entry Name:
- VKGC_HUMAN
- Status:
- reviewed
- Protein Names:
- Vitamin K-dependent gamma-carboxylase (EC 4.1.1.90) (Gamma-glutamyl carboxylase) (Peptidyl-glutamate 4-carboxylase) (Vitamin K gamma glutamyl carboxylase)
- Gene Names:
- GGCX GC
- Gene Names Primary:
- GGCX
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 758
- Sequence:
- MAVSAGSARTSPSSDKVQKDKAELISGPRQDSRIGKLLGFEWTDLSSWRRLVTLLNRPTDPASLAVFRFLFGFLMVLDIPQERGLSSLDRKYLDGLDVCRFPLLDALRPLPLDWMYLVYTIMFLGALGMMLGLCYRISCVLFLLPYWYVFLLDKTSWNNHSYLYGLLAFQLTFMDANHYWSVDGLLNAHRRNAHVPLWNYAVLRGQIFIVYFIAGVKKLDADWVEGYSMEYLSRHWLFSPFKLLLSEELTSLLVVHWGGLLLDLSAGFLLFFDVSRSIGLFFVSYFHCMNSQLFSIGMFSYVMLASSPLFCSPEWPRKLVSYCPRRLQQLLPLKAAPQPSVSCVYKRSRGKSGQKPGLRHQLGAAFTLLYLLEQLFLPYSHFLTQGYNNWTNGLYGYSWDMMVHSRSHQHVKITYRDGRTGELGYLNPGVFTQSRRWKDHADMLKQYATCLSRLLPKYNVTEPQIYFDIWVSINDRFQQRIFDPRVDIVQAAWSPFQRTSWVQPLLMDLSPWRAKLQEIKSSLDNHTEVVFIADFPGLHLENFVSEDLGNTSIQLLQGEVTVELVAEQKNQTLREGEKMQLPAGEYHKVYTTSPSPSCYMYVYVNTTELALEQDLAYLQELKEKVENGSETGPLPPELQPLLEGEVKGGPEPTPLVQTFLRRQQRLQEIERRRNTPFHERFFRFLLRKLYVFRRSFLMTCISLRNLILGRPSLEQLAQEVTYANLRPFEAVGELNPSNTDSSHSNPPESNPDPVHSEF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.
- Catalytic Activity:
- -4-carboxyglutamate + 2,3-epoxyphylloquinone + H(2)O = -glutamate + CO(2) + O(2) + phylloquinol.
- Active Site:
- ACT_SITE 218 218 Proton acceptor.
- Cross Reference Drug Bank:
- DB01125 DB00100 DB00036 DB00055 DB00170 DB01022
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of membrane
membrane
gamma-glutamyl carboxylase activity
blood coagulation
cellular protein metabolic process
cellular protein modification process
peptidyl-glutamic acid carboxylation
post-translational protein modification - Gene Ontology Biological Process:
- blood coagulation
cellular protein metabolic process
cellular protein modification process
peptidyl-glutamic acid carboxylation
post-translational protein modification - Gene Ontology Molecular Function:
- gamma-glutamyl carboxylase activity
- Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of membrane
membrane - Keywords:
- Acetylation
Alternative splicing
Complete proteome
Disease mutation
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Lyase
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix