Names & Taxonomy

Uniprot ID:
P38435
Entry Name:
VKGC_HUMAN
Status:
reviewed
Protein Names:
Vitamin K-dependent gamma-carboxylase (EC 4.1.1.90) (Gamma-glutamyl carboxylase) (Peptidyl-glutamate 4-carboxylase) (Vitamin K gamma glutamyl carboxylase)
Gene Names:
GGCX GC
Gene Names Primary:
GGCX
Organism:
Homo sapiens (Human)

Structure

Length:
758
Sequence:
MAVSAGSARTSPSSDKVQKDKAELISGPRQDSRIGKLLGFEWTDLSSWRRLVTLLNRPTDPASLAVFRFLFGFLMVLDIPQERGLSSLDRKYLDGLDVCRFPLLDALRPLPLDWMYLVYTIMFLGALGMMLGLCYRISCVLFLLPYWYVFLLDKTSWNNHSYLYGLLAFQLTFMDANHYWSVDGLLNAHRRNAHVPLWNYAVLRGQIFIVYFIAGVKKLDADWVEGYSMEYLSRHWLFSPFKLLLSEELTSLLVVHWGGLLLDLSAGFLLFFDVSRSIGLFFVSYFHCMNSQLFSIGMFSYVMLASSPLFCSPEWPRKLVSYCPRRLQQLLPLKAAPQPSVSCVYKRSRGKSGQKPGLRHQLGAAFTLLYLLEQLFLPYSHFLTQGYNNWTNGLYGYSWDMMVHSRSHQHVKITYRDGRTGELGYLNPGVFTQSRRWKDHADMLKQYATCLSRLLPKYNVTEPQIYFDIWVSINDRFQQRIFDPRVDIVQAAWSPFQRTSWVQPLLMDLSPWRAKLQEIKSSLDNHTEVVFIADFPGLHLENFVSEDLGNTSIQLLQGEVTVELVAEQKNQTLREGEKMQLPAGEYHKVYTTSPSPSCYMYVYVNTTELALEQDLAYLQELKEKVENGSETGPLPPELQPLLEGEVKGGPEPTPLVQTFLRRQQRLQEIERRRNTPFHERFFRFLLRKLYVFRRSFLMTCISLRNLILGRPSLEQLAQEVTYANLRPFEAVGELNPSNTDSSHSNPPESNPDPVHSEF
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane

Function

Function:
Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.
Catalytic Activity:
-4-carboxyglutamate + 2,3-epoxyphylloquinone + H(2)O = -glutamate + CO(2) + O(2) + phylloquinol.
Active Site:
ACT_SITE 218 218 Proton acceptor.
Cross Reference Drug Bank:
DB01125 DB00100 DB00036 DB00055 DB00170 DB01022
Gene Ontology Go:
endoplasmic reticulum membrane
integral component of membrane
membrane
gamma-glutamyl carboxylase activity
blood coagulation
cellular protein metabolic process
cellular protein modification process
peptidyl-glutamic acid carboxylation
post-translational protein modification
Gene Ontology Biological Process:
blood coagulation
cellular protein metabolic process
cellular protein modification process
peptidyl-glutamic acid carboxylation
post-translational protein modification
Gene Ontology Molecular Function:
gamma-glutamyl carboxylase activity
Gene Ontology Cellular Component:
endoplasmic reticulum membrane
integral component of membrane
membrane
Keywords:
Acetylation
Alternative splicing
Complete proteome
Disease mutation
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Lyase
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix

Publication

PubMed ID:
1749935 9166845 14702039 15815621 15489334 10910912 11570873 12963724 16011462 17073445 19413330 19159218 21406692 24275569 9845520 11071668 10934213 15287948 17110937