Names & Taxonomy
- Uniprot ID:
- P37288
- Entry Name:
- V1AR_HUMAN
- Status:
- reviewed
- Protein Names:
- Vasopressin V1a receptor (V1aR) (AVPR V1a) (Antidiuretic hormone receptor 1a) (Vascular/hepatic-type arginine vasopressin receptor)
- Gene Names:
- AVPR1A AVPR1
- Gene Names Primary:
- AVPR1A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 418
- Sequence:
- MRLSAGPDAGPSGNSSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAVTFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGPDWLCRVVKHLQVFGMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFVLSTPQYFVFSMIEVNNVTKARDCWATFIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFICYNIWCNVRGKTASRQSKGAEQAGVAFQKGFLLAPCVSSVKSISRAKIRTVKMTFVIVTAYIVCWAPFFIIQMWSVWDPMSVWTESENPTITITALLGSLNSCCNPWIYMFFSGHLLQDCVQSFPCCQNMKEKFNKEDTDSMSRRQTFYSNNRSPTNSTGMWKDSPKSSKSIKFIPVST
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment.
- Cross Reference Drug Bank:
- DB00872 DB00035 DB00093 DB02638 DB06212 DB00067
- Gene Ontology Go:
- cytoplasmic vesicle
cytosol
endosome
integral component of plasma membrane
plasma membrane
peptide binding
peptide hormone binding
protein kinase C binding
vasopressin receptor activity
activation of phospholipase C activity
blood circulation
calcium-mediated signaling
cellular response to hormone stimulus
cellular response to water deprivation
G-protein coupled receptor signaling pathway
generation of precursor metabolites and energy
grooming behavior
maternal aggressive behavior
maternal behavior
myotube differentiation
negative regulation of female receptivity
negative regulation of transmission of nerve impulse
penile erection
positive regulation of cell growth
positive regulation of cell proliferation
positive regulation of cellular pH reduction
positive regulation of cytosolic calcium ion concentration
positive regulation of glutamate secretion
positive regulation of heart rate
positive regulation of prostaglandin biosynthetic process
positive regulation of renal sodium excretion
positive regulation of systemic arterial blood pressure
positive regulation of vasoconstriction
regulation of systemic arterial blood pressure by vasopressin
response to corticosterone
response to peptide
social behavior
sperm ejaculation
telencephalon development - Gene Ontology Biological Process:
- activation of phospholipase C activity
blood circulation
calcium-mediated signaling
cellular response to hormone stimulus
cellular response to water deprivation
generation of precursor metabolites and energy
G-protein coupled receptor signaling pathway
grooming behavior
maternal aggressive behavior
maternal behavior
myotube differentiation
negative regulation of female receptivity
negative regulation of transmission of nerve impulse
penile erection
positive regulation of cell growth
positive regulation of cell proliferation
positive regulation of cellular pH reduction
positive regulation of cytosolic calcium ion concentration
positive regulation of glutamate secretion
positive regulation of heart rate
positive regulation of prostaglandin biosynthetic process
positive regulation of renal sodium excretion
positive regulation of systemic arterial blood pressure
positive regulation of vasoconstriction
regulation of systemic arterial blood pressure by vasopressin
response to corticosterone
response to peptide
social behavior
sperm ejaculation
telencephalon development - Gene Ontology Molecular Function:
- peptide binding
peptide hormone binding
protein kinase C binding
vasopressin receptor activity - Gene Ontology Cellular Component:
- cytoplasmic vesicle
cytosol
endosome
integral component of plasma membrane
plasma membrane - Keywords:
- 3D-structure
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Palmitate
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix