Names & Taxonomy
- Uniprot ID:
- P37231
- Entry Name:
- PPARG_HUMAN
- Status:
- reviewed
- Protein Names:
- Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3)
- Gene Names:
- PPARG NR1C3
- Gene Names Primary:
- PPARG
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 505
- Sequence:
- MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus. Cytoplasm. Note=Redistributed from the nucleus to the cytosol through a MAP2K1/MEK1-dependent manner. NOCT enhances its nuclear translocation.
Function
- Function:
- Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity).
- Enzyme Regulation:
- ENZYME REGULATION: PDPK1 activates its transcriptional activity independently of its kinase activity.
- Cross Reference Drug Bank:
- DB01014 DB01393 DB01067 DB01050 DB00159 DB00328 DB00244 DB01252 DB00731 DB01132 DB00912 DB00412 DB00795 DB00966
- Gene Ontology Go:
- cytosol
Golgi apparatus
intracellular membrane-bounded organelle
nucleoplasm
nucleus
perinuclear region of cytoplasm
RNA polymerase II transcription factor complex
activating transcription factor binding
alpha-actinin binding
arachidonic acid binding
chromatin binding
core promoter sequence-specific DNA binding
DNA binding
drug binding
enzyme binding
identical protein binding
ligand-dependent nuclear receptor transcription coactivator activity
prostaglandin receptor activity
retinoid X receptor binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
steroid hormone receptor activity
transcription factor activity, sequence-specific DNA binding
transcription regulatory region DNA binding
zinc ion binding
activation of cysteine-type endopeptidase activity involved in apoptotic process
cell fate commitment
cell maturation
cellular response to hyperoxia
cellular response to insulin stimulus
cellular response to prostaglandin E stimulus
cellular response to retinoic acid
cellular response to vitamin E
epithelial cell differentiation
fatty acid oxidation
G-protein coupled receptor signaling pathway
gene expression
glucose homeostasis
heart development
innate immune response
lipid homeostasis
lipid metabolic process
lipoprotein transport
long-chain fatty acid transport
low-density lipoprotein particle receptor biosynthetic process
monocyte differentiation
negative regulation of acute inflammatory response
negative regulation of cell growth
negative regulation of cholesterol storage
negative regulation of collagen biosynthetic process
negative regulation of interferon-gamma-mediated signaling pathway
negative regulation of macrophage derived foam cell differentiation
negative regulation of pancreatic stellate cell proliferation
negative regulation of receptor biosynthetic process
negative regulation of sequestering of triglyceride
negative regulation of smooth muscle cell proliferation
negative regulation of telomerase activity
negative regulation of transcription from RNA polymerase II promoter
negative regulation of transcription, DNA-templated
organ regeneration
peroxisome proliferator activated receptor signaling pathway
placenta development
positive regulation of fat cell differentiation
positive regulation of fatty acid oxidation
positive regulation of oligodendrocyte differentiation
positive regulation of phagocytosis, engulfment
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
regulation of blood pressure
regulation of cholesterol transporter activity
regulation of circadian rhythm
regulation of transcription involved in cell fate commitment
response to caffeine
response to cold
response to diuretic
response to estrogen
response to immobilization stress
response to lipid
response to low-density lipoprotein particle
response to mechanical stimulus
response to metformin
response to nutrient
response to retinoic acid
response to starvation
response to vitamin A
rhythmic process
signal transduction
transcription initiation from RNA polymerase II promoter
white fat cell differentiation - Gene Ontology Biological Process:
- activation of cysteine-type endopeptidase activity involved in apoptotic process
cell fate commitment
cell maturation
cellular response to hyperoxia
cellular response to insulin stimulus
cellular response to prostaglandin E stimulus
cellular response to retinoic acid
cellular response to vitamin E
epithelial cell differentiation
fatty acid oxidation
gene expression
glucose homeostasis
G-protein coupled receptor signaling pathway
heart development
innate immune response
lipid homeostasis
lipid metabolic process
lipoprotein transport
long-chain fatty acid transport
low-density lipoprotein particle receptor biosynthetic process
monocyte differentiation
negative regulation of acute inflammatory response
negative regulation of cell growth
negative regulation of cholesterol storage
negative regulation of collagen biosynthetic process
negative regulation of interferon-gamma-mediated signaling pathway
negative regulation of macrophage derived foam cell differentiation
negative regulation of pancreatic stellate cell proliferation
negative regulation of receptor biosynthetic process
negative regulation of sequestering of triglyceride
negative regulation of smooth muscle cell proliferation
negative regulation of telomerase activity
negative regulation of transcription, DNA-templated
negative regulation of transcription from RNA polymerase II promoter
organ regeneration
peroxisome proliferator activated receptor signaling pathway
placenta development
positive regulation of fat cell differentiation
positive regulation of fatty acid oxidation
positive regulation of oligodendrocyte differentiation
positive regulation of phagocytosis, engulfment
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of blood pressure
regulation of cholesterol transporter activity
regulation of circadian rhythm
regulation of transcription involved in cell fate commitment
response to caffeine
response to cold
response to diuretic
response to estrogen
response to immobilization stress
response to lipid
response to low-density lipoprotein particle
response to mechanical stimulus
response to metformin
response to nutrient
response to retinoic acid
response to starvation
response to vitamin A
rhythmic process
signal transduction
transcription initiation from RNA polymerase II promoter
white fat cell differentiation - Gene Ontology Molecular Function:
- activating transcription factor binding
alpha-actinin binding
arachidonic acid binding
chromatin binding
core promoter sequence-specific DNA binding
DNA binding
drug binding
enzyme binding
identical protein binding
ligand-dependent nuclear receptor transcription coactivator activity
prostaglandin receptor activity
retinoid X receptor binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
steroid hormone receptor activity
transcription factor activity, sequence-specific DNA binding
transcription regulatory region DNA binding
zinc ion binding - Gene Ontology Cellular Component:
- cytosol
Golgi apparatus
intracellular membrane-bounded organelle
nucleoplasm
nucleus
perinuclear region of cytoplasm
RNA polymerase II transcription factor complex - Keywords:
- 3D-structure
Activator
Alternative splicing
Biological rhythms
Complete proteome
Cytoplasm
DNA-binding
Diabetes mellitus
Disease mutation
Glycoprotein
Metal-binding
Nucleus
Obesity
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Transcription
Transcription regulation
Zinc
Zinc-finger - Interacts With:
- Itself; Q00535; P10909; O60869; P42858; Q6STE5-1; Q6STE5-2
Publication
- PubMed ID:
- 9065481 8702406 9144532 7787419 9356045 8706692 16842753 14702039 16641997 15489334 10681503 10851250 12039952 11971969 15047147 15687259 16239304 16150867 17101779 20829347 21047783 22351778 23525231 9813012 9744270 10882139 11698662 11587644 12672231 15258145 15056000 15974597 15976031 16919947 16451087 16640330 9425261 9753710 9806549 10407229 10523018 10394368 10622252 12453919 11788685 14569127 15356014 15562396