Names & Taxonomy
- Uniprot ID:
- P37173
- Entry Name:
- TGFR2_HUMAN
- Status:
- reviewed
- Protein Names:
- TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II)
- Gene Names:
- TGFBR2
- Gene Names Primary:
- TGFBR2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 567
- Sequence:
- MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPEDGSLNTTK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.
- Catalytic Activity:
- ATP + = ADP + phosphate.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Active Site:
- ACT_SITE 379 379 Proton acceptor.
- Gene Ontology Go:
- caveola
cytosol
external side of plasma membrane
integral component of membrane
membrane raft
plasma membrane
receptor complex
transforming growth factor beta receptor homodimeric complex
ATP binding
glycosaminoglycan binding
metal ion binding
receptor signaling protein serine/threonine kinase activity
SMAD binding
transforming growth factor beta binding
transforming growth factor beta receptor activity, type II
transforming growth factor beta-activated receptor activity
transmembrane receptor protein serine/threonine kinase activity
type I transforming growth factor beta receptor binding
type III transforming growth factor beta receptor binding
activation of protein kinase activity
aging
apoptotic process
blood vessel development
brain development
bronchus morphogenesis
common-partner SMAD protein phosphorylation
digestive tract development
embryo implantation
embryonic cranial skeleton morphogenesis
embryonic hemopoiesis
gastrulation
growth plate cartilage chondrocyte growth
heart development
in utero embryonic development
lens development in camera-type eye
lens fiber cell apoptotic process
lung lobe morphogenesis
mammary gland morphogenesis
myeloid dendritic cell differentiation
negative regulation of cardiac muscle cell proliferation
negative regulation of transforming growth factor beta receptor signaling pathway
Notch signaling pathway
organ regeneration
palate development
pathway-restricted SMAD protein phosphorylation
patterning of blood vessels
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
positive regulation of angiogenesis
positive regulation of B cell tolerance induction
positive regulation of cell proliferation
positive regulation of epithelial cell migration
positive regulation of epithelial to mesenchymal transition
positive regulation of mesenchymal cell proliferation
positive regulation of NK T cell differentiation
positive regulation of reactive oxygen species metabolic process
positive regulation of skeletal muscle tissue regeneration
positive regulation of smooth muscle cell proliferation
positive regulation of T cell tolerance induction
positive regulation of tolerance induction to self antigen
protein phosphorylation
receptor-mediated endocytosis
regulation of cell proliferation
regulation of gene expression
response to cholesterol
response to drug
response to estrogen
response to glucose
response to mechanical stimulus
response to nutrient
smoothened signaling pathway
trachea formation
transforming growth factor beta receptor signaling pathway
vasculogenesis
wound healing - Gene Ontology Biological Process:
- activation of protein kinase activity
aging
apoptotic process
blood vessel development
brain development
bronchus morphogenesis
common-partner SMAD protein phosphorylation
digestive tract development
embryo implantation
embryonic cranial skeleton morphogenesis
embryonic hemopoiesis
gastrulation
growth plate cartilage chondrocyte growth
heart development
in utero embryonic development
lens development in camera-type eye
lens fiber cell apoptotic process
lung lobe morphogenesis
mammary gland morphogenesis
myeloid dendritic cell differentiation
negative regulation of cardiac muscle cell proliferation
negative regulation of transforming growth factor beta receptor signaling pathway
Notch signaling pathway
organ regeneration
palate development
pathway-restricted SMAD protein phosphorylation
patterning of blood vessels
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
positive regulation of angiogenesis
positive regulation of B cell tolerance induction
positive regulation of cell proliferation
positive regulation of epithelial cell migration
positive regulation of epithelial to mesenchymal transition
positive regulation of mesenchymal cell proliferation
positive regulation of NK T cell differentiation
positive regulation of reactive oxygen species metabolic process
positive regulation of skeletal muscle tissue regeneration
positive regulation of smooth muscle cell proliferation
positive regulation of T cell tolerance induction
positive regulation of tolerance induction to self antigen
protein phosphorylation
receptor-mediated endocytosis
regulation of cell proliferation
regulation of gene expression
response to cholesterol
response to drug
response to estrogen
response to glucose
response to mechanical stimulus
response to nutrient
smoothened signaling pathway
trachea formation
transforming growth factor beta receptor signaling pathway
vasculogenesis
wound healing - Gene Ontology Molecular Function:
- ATP binding
glycosaminoglycan binding
metal ion binding
receptor signaling protein serine/threonine kinase activity
SMAD binding
transforming growth factor beta-activated receptor activity
transforming growth factor beta binding
transforming growth factor beta receptor activity, type II
transmembrane receptor protein serine/threonine kinase activity
type III transforming growth factor beta receptor binding
type I transforming growth factor beta receptor binding - Gene Ontology Cellular Component:
- caveola
cytosol
external side of plasma membrane
integral component of membrane
membrane raft
plasma membrane
receptor complex
transforming growth factor beta receptor homodimeric complex - Keywords:
- 3D-structure
ATP-binding
Alternative splicing
Aortic aneurysm
Apoptosis
Cell membrane
Complete proteome
Differentiation
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Growth regulation
Hereditary nonpolyposis colorectal cancer
Kinase
Magnesium
Manganese
Membrane
Metal-binding
Nucleotide-binding
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Serine/threonine-protein kinase
Signal
Transferase
Transmembrane
Transmembrane helix - Interacts With:
- Q9UER7; Q93074; A2AGH6; Q8IX30; P01137; P07200; P10600
Publication
- PubMed ID:
- 1310899 7959019 8812462 8840968 8973329 14702039 15340161 7774578 9865696 9472030 11483955 12941698 16982625 18691976 19369195 21441952 24275569 25893292 11850637 12121646 12939140 18243111 20207738 9590282 10789724 11212236 12202987 15235604 16027248 15731757 16251899 16959974 17344846 19883511 20101701 20358619 22113417 21949523