Names & Taxonomy
- Uniprot ID:
- P36896
- Entry Name:
- ACV1B_HUMAN
- Status:
- reviewed
- Protein Names:
- Activin receptor type-1B (EC 2.7.11.30) (Activin receptor type IB) (ACTR-IB) (Activin receptor-like kinase 4) (ALK-4) (Serine/threonine-protein kinase receptor R2) (SKR2)
- Gene Names:
- ACVR1B ACVRLK4 ALK4
- Gene Names Primary:
- ACVR1B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 505
- Sequence:
- MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQEDVKI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2.
- Catalytic Activity:
- ATP + = ADP + phosphate.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Enzyme Regulation:
- ENZYME REGULATION: Activin receptor type-2 (ACVR2A or ACVR2B) activates the type-1 receptor through phosphorylation of its regulatory GS domain.
- Active Site:
- ACT_SITE 335 335 Proton acceptor.
- Cross Reference Drug Bank:
- DB00171
- Gene Ontology Go:
- activin receptor complex
cell surface
extracellular exosome
integral component of plasma membrane
plasma membrane
receptor complex
activin receptor activity, type I
ATP binding
inhibin binding
metal ion binding
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
SMAD binding
transmembrane receptor protein serine/threonine kinase activity
ubiquitin protein ligase binding
activin receptor signaling pathway
central nervous system development
development of primary female sexual characteristics
extrinsic apoptotic signaling pathway
G1/S transition of mitotic cell cycle
hair follicle development
in utero embryonic development
negative regulation of cell growth
negative regulation of gene expression
nodal signaling pathway
peptidyl-threonine phosphorylation
positive regulation of activin receptor signaling pathway
positive regulation of erythrocyte differentiation
positive regulation of pathway-restricted SMAD protein phosphorylation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of trophoblast cell migration
protein autophosphorylation
protein phosphorylation
regulation of transcription, DNA-templated
signal transduction
transmembrane receptor protein serine/threonine kinase signaling pathway - Gene Ontology Biological Process:
- activin receptor signaling pathway
central nervous system development
development of primary female sexual characteristics
extrinsic apoptotic signaling pathway
G1/S transition of mitotic cell cycle
hair follicle development
in utero embryonic development
negative regulation of cell growth
negative regulation of gene expression
nodal signaling pathway
peptidyl-threonine phosphorylation
positive regulation of activin receptor signaling pathway
positive regulation of erythrocyte differentiation
positive regulation of pathway-restricted SMAD protein phosphorylation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of trophoblast cell migration
protein autophosphorylation
protein phosphorylation
regulation of transcription, DNA-templated
signal transduction
transmembrane receptor protein serine/threonine kinase signaling pathway - Gene Ontology Molecular Function:
- activin receptor activity, type I
ATP binding
inhibin binding
metal ion binding
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
SMAD binding
transmembrane receptor protein serine/threonine kinase activity
ubiquitin protein ligase binding - Gene Ontology Cellular Component:
- activin receptor complex
cell surface
extracellular exosome
integral component of plasma membrane
plasma membrane
receptor complex - Keywords:
- ATP-binding
Alternative splicing
Cell membrane
Complete proteome
Glycoprotein
Kinase
Magnesium
Manganese
Membrane
Metal-binding
Nucleotide-binding
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Serine/threonine-protein kinase
Signal
Transferase
Transmembrane
Transmembrane helix
Ubl conjugation - Interacts With:
- P62942; P08238; O15105