Names & Taxonomy
- Uniprot ID:
- P35610
- Entry Name:
- SOAT1_HUMAN
- Status:
- reviewed
- Protein Names:
- Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1)
- Gene Names:
- SOAT1 ACACT ACACT1 ACAT ACAT1 SOAT STAT
- Gene Names Primary:
- SOAT1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 550
- Sequence:
- MVGEEKMSLRNRLSKSRENPEEDEDQRNPAKESLETPSNGRIDIKQLIAKKIKLTAEAEELKPFFMKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSVLEGEKNNHRAKDLRAPPEQGKIFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGKFPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPLIRSLFHGFLFMIFQIGVLGFGPTYVVLAYTLPPASRFIIIFEQIRFVMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFMFFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYARQHCPLKNPTFLDYVRPRSWTCRYVF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase.
- Catalytic Activity:
- Acyl-CoA + cholesterol = CoA + cholesterol ester.
- Active Site:
- ACT_SITE 460 460
- Cross Reference Drug Bank:
- DB00973 DB01094
- Gene Ontology Go:
- endoplasmic reticulum
endoplasmic reticulum membrane
integral component of membrane
membrane
cholesterol binding
cholesterol O-acyltransferase activity
fatty-acyl-CoA binding
sterol O-acyltransferase activity
cholesterol efflux
cholesterol esterification
cholesterol homeostasis
cholesterol metabolic process
cholesterol storage
macrophage derived foam cell differentiation
positive regulation of amyloid precursor protein biosynthetic process
very-low-density lipoprotein particle assembly - Gene Ontology Biological Process:
- cholesterol efflux
cholesterol esterification
cholesterol homeostasis
cholesterol metabolic process
cholesterol storage
macrophage derived foam cell differentiation
positive regulation of amyloid precursor protein biosynthetic process
very-low-density lipoprotein particle assembly - Gene Ontology Molecular Function:
- cholesterol binding
cholesterol O-acyltransferase activity
fatty-acyl-CoA binding
sterol O-acyltransferase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum
endoplasmic reticulum membrane
integral component of membrane
membrane - Keywords:
- Acetylation
Acyltransferase
Alternative splicing
Cholesterol metabolism
Complete proteome
Disulfide bond
Endoplasmic reticulum
Lipid metabolism
Membrane
Polymorphism
Reference proteome
Steroid metabolism
Sterol metabolism
Transferase
Transmembrane
Transmembrane helix - Interacts With:
- P54274; Q9Y5Z9