Names & Taxonomy

Uniprot ID:
P35610
Entry Name:
SOAT1_HUMAN
Status:
reviewed
Protein Names:
Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1)
Gene Names:
SOAT1 ACACT ACACT1 ACAT ACAT1 SOAT STAT
Gene Names Primary:
SOAT1
Organism:
Homo sapiens (Human)

Structure

Length:
550
Sequence:
MVGEEKMSLRNRLSKSRENPEEDEDQRNPAKESLETPSNGRIDIKQLIAKKIKLTAEAEELKPFFMKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSVLEGEKNNHRAKDLRAPPEQGKIFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGKFPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPLIRSLFHGFLFMIFQIGVLGFGPTYVVLAYTLPPASRFIIIFEQIRFVMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFMFFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYARQHCPLKNPTFLDYVRPRSWTCRYVF
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane

Function

Function:
Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase.
Catalytic Activity:
Acyl-CoA + cholesterol = CoA + cholesterol ester.
Active Site:
ACT_SITE 460 460
Cross Reference Drug Bank:
DB00973 DB01094
Gene Ontology Go:
endoplasmic reticulum
endoplasmic reticulum membrane
integral component of membrane
membrane
cholesterol binding
cholesterol O-acyltransferase activity
fatty-acyl-CoA binding
sterol O-acyltransferase activity
cholesterol efflux
cholesterol esterification
cholesterol homeostasis
cholesterol metabolic process
cholesterol storage
macrophage derived foam cell differentiation
positive regulation of amyloid precursor protein biosynthetic process
very-low-density lipoprotein particle assembly
Gene Ontology Biological Process:
cholesterol efflux
cholesterol esterification
cholesterol homeostasis
cholesterol metabolic process
cholesterol storage
macrophage derived foam cell differentiation
positive regulation of amyloid precursor protein biosynthetic process
very-low-density lipoprotein particle assembly
Gene Ontology Molecular Function:
cholesterol binding
cholesterol O-acyltransferase activity
fatty-acyl-CoA binding
sterol O-acyltransferase activity
Gene Ontology Cellular Component:
endoplasmic reticulum
endoplasmic reticulum membrane
integral component of membrane
membrane
Keywords:
Acetylation
Acyltransferase
Alternative splicing
Cholesterol metabolism
Complete proteome
Disulfide bond
Endoplasmic reticulum
Lipid metabolism
Membrane
Polymorphism
Reference proteome
Steroid metabolism
Sterol metabolism
Transferase
Transmembrane
Transmembrane helix
Interacts With:
P54274; Q9Y5Z9

Publication

PubMed ID:
8407899 14702039 16710414 15489334 10438503 16154994 18480028 22814378 23169578