Names & Taxonomy
- Uniprot ID:
- P35609
- Entry Name:
- ACTN2_HUMAN
- Status:
- reviewed
- Protein Names:
- Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein)
- Gene Names:
- ACTN2
- Gene Names Primary:
- ACTN2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 894
- Sequence:
- MNQIEPGVQYNYVYDEDEYMIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLLTTIARTINEVETQILTRDAKGITQEQMNEFRASFNHFDRRKNGLMDHEDFRACLISMGYDLGEAEFARIMTLVDPNGQGTVTFQSFIDFMTRETADTDTAEQVIASFRILASDKPYILAEELRRELPPDQAQYCIKRMPAYSGPGSVPGALDYAAFSSALYGESDL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, myofibril, sarcomere, Z line
Function
- Function:
- F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
- Gene Ontology Go:
- actin filament
cortical actin cytoskeleton
cytoskeleton
cytosol
dendritic spine
extracellular exosome
extracellular region
filopodium
focal adhesion
platelet alpha granule lumen
pseudopodium
Z disc
calcium ion binding
cytoskeletal protein binding
FATZ binding
identical protein binding
integrin binding
ion channel binding
phosphatidylinositol-4,5-bisphosphate binding
protein dimerization activity
protein domain specific binding
protein homodimerization activity
structural constituent of muscle
thyroid hormone receptor coactivator activity
titin binding
titin Z domain binding
actin filament uncapping
activation of MAPKK activity
axon guidance
blood coagulation
cardiac muscle cell development
cell adhesion
epidermal growth factor receptor signaling pathway
establishment of protein localization to plasma membrane
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
focal adhesion assembly
innate immune response
insulin receptor signaling pathway
MAPK cascade
microspike assembly
muscle filament sliding
negative regulation of potassium ion transmembrane transporter activity
negative regulation of potassium ion transport
negative regulation of protein localization to cell surface
neurotrophin TRK receptor signaling pathway
phospholipase C-activating angiotensin-activated signaling pathway
platelet activation
platelet degranulation
positive regulation of cation channel activity
positive regulation of endocytic recycling
positive regulation of potassium ion transmembrane transporter activity
positive regulation of potassium ion transport
protein homotetramerization
Ras protein signal transduction
regulation of apoptotic process
regulation of membrane potential
sarcomere organization
small GTPase mediated signal transduction
synaptic transmission
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Biological Process:
- actin filament uncapping
activation of MAPKK activity
axon guidance
blood coagulation
cardiac muscle cell development
cell adhesion
epidermal growth factor receptor signaling pathway
establishment of protein localization to plasma membrane
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
focal adhesion assembly
innate immune response
insulin receptor signaling pathway
MAPK cascade
microspike assembly
muscle filament sliding
negative regulation of potassium ion transmembrane transporter activity
negative regulation of potassium ion transport
negative regulation of protein localization to cell surface
neurotrophin TRK receptor signaling pathway
phospholipase C-activating angiotensin-activated signaling pathway
platelet activation
platelet degranulation
positive regulation of cation channel activity
positive regulation of endocytic recycling
positive regulation of potassium ion transmembrane transporter activity
positive regulation of potassium ion transport
protein homotetramerization
Ras protein signal transduction
regulation of apoptotic process
regulation of membrane potential
sarcomere organization
small GTPase mediated signal transduction
synaptic transmission
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Molecular Function:
- calcium ion binding
cytoskeletal protein binding
FATZ binding
identical protein binding
integrin binding
ion channel binding
phosphatidylinositol-4,5-bisphosphate binding
protein dimerization activity
protein domain specific binding
protein homodimerization activity
structural constituent of muscle
thyroid hormone receptor coactivator activity
titin binding
titin Z domain binding - Gene Ontology Cellular Component:
- actin filament
cortical actin cytoskeleton
cytoskeleton
cytosol
dendritic spine
extracellular exosome
extracellular region
filopodium
focal adhesion
platelet alpha granule lumen
pseudopodium
Z disc - Keywords:
- 3D-structure
Acetylation
Actin-binding
Alternative splicing
Calcium
Cardiomyopathy
Complete proteome
Cytoplasm
Disease mutation
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Ubl conjugation - Interacts With:
- Itself; Q61824; P03950; Q9UKG1; Q5PSV4; Q9NRI5; O75923; P22460; Q8IY33; P00540; P54296; Q9NPC6; Q53GG5; Q14D33; Q8IYX7; O95863; P23497; Q8WZ42