Names & Taxonomy

Uniprot ID:
P35568
Entry Name:
IRS1_HUMAN
Status:
reviewed
Protein Names:
Insulin receptor substrate 1 (IRS-1)
Gene Names:
IRS1
Gene Names Primary:
IRS1
Organism:
Homo sapiens (Human)

Structure

Length:
1242
Sequence:
MASPPESDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAPKRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGHHDGAAALGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLIGIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQVDDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLTRRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHRGSARLHPPLNHSRSIPMPASRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSPSDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGPSTLTAPNGHYILSRGGNGHRCTPGTGLGTSPALAGDEAASAADLDNRFRKRTHSAGTSPTITHQKTPSQSSVASIEEYTEMMPAYPPGGGSGGRLPGHRHSAFVPTRSYPEEGLEMHPLERRGGHHRPDSSTLHTDDGYMPMSPGVAPVPSGRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPNGYMMMSPSGGCSPDIGGGPSSSSSSSNAVPSGTSYGKLWTNGVGGHHSHVLPHPKPPVESSGGKLLPCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEPEEGARHQHLRLSTSSGRLLYAATADDSSSSTSSDSLGGGYCGARLEPSLPHPHHQVLQPHLPRKVDTAAQTNSRLARPTRLSLGDPKASTLPRAREQQQQQQPLLHPPEPKSPGEYVNIEFGSDQSGYLSGPVAFHSSPSVRCPSQLQPAPREEETGTEEYMKMDLGPGRRAAWQESTGVEMGRLGPAPPGAASICRPTRAVPSSRGDYMTMQMSCPRQSYVDTSPAAPVSYADMRTGIAAEEVSLPRATMAAASSSSAASASPTGPQGAAELAAHSSLLGGPQGPGGMSAFTRVNLSPNRNQSAKVIRADPQGCRRRHSSETFSSTPSATRVGNTVPFGAGAAVGGGGGSSSSSEDVKRHSSASFENVWLRPGELGGAPKEPAKLCGAAGGLENGLNYIDLDLVKDFKQCPQECTPEPQPPPPPPPHQPLGSGESSSTRRSSEDLSAYASISFQKQPEDRQ
Proteomes:
UP000005640

Function

Function:
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).
Gene Ontology Go:
caveola
cytoplasm
cytosol
insulin receptor complex
intracellular membrane-bounded organelle
nucleus
plasma membrane
insulin receptor binding
insulin-like growth factor receptor binding
phosphatidylinositol 3-kinase binding
protein kinase C binding
SH2 domain binding
signal transducer activity
transmembrane receptor protein tyrosine kinase adaptor activity
activation of MAPKK activity
axon guidance
cellular response to insulin stimulus
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
glucose homeostasis
innate immune response
insulin receptor signaling pathway
insulin-like growth factor receptor signaling pathway
JAK-STAT cascade involved in growth hormone signaling pathway
MAPK cascade
negative regulation of insulin receptor signaling pathway
negative regulation of insulin secretion
neurotrophin TRK receptor signaling pathway
phosphatidylinositol 3-kinase signaling
phosphatidylinositol-mediated signaling
positive regulation of cell proliferation
positive regulation of fatty acid beta-oxidation
positive regulation of glucose import
positive regulation of glucose import in response to insulin stimulus
positive regulation of glucose metabolic process
positive regulation of glycogen biosynthetic process
positive regulation of insulin receptor signaling pathway
positive regulation of phosphatidylinositol 3-kinase activity
Ras protein signal transduction
response to insulin
response to peptide hormone
signal transduction
small GTPase mediated signal transduction
vascular endothelial growth factor receptor signaling pathway
Gene Ontology Biological Process:
activation of MAPKK activity
axon guidance
cellular response to insulin stimulus
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
glucose homeostasis
innate immune response
insulin-like growth factor receptor signaling pathway
insulin receptor signaling pathway
JAK-STAT cascade involved in growth hormone signaling pathway
MAPK cascade
negative regulation of insulin receptor signaling pathway
negative regulation of insulin secretion
neurotrophin TRK receptor signaling pathway
phosphatidylinositol 3-kinase signaling
phosphatidylinositol-mediated signaling
positive regulation of cell proliferation
positive regulation of fatty acid beta-oxidation
positive regulation of glucose import
positive regulation of glucose import in response to insulin stimulus
positive regulation of glucose metabolic process
positive regulation of glycogen biosynthetic process
positive regulation of insulin receptor signaling pathway
positive regulation of phosphatidylinositol 3-kinase activity
Ras protein signal transduction
response to insulin
response to peptide hormone
signal transduction
small GTPase mediated signal transduction
vascular endothelial growth factor receptor signaling pathway
Gene Ontology Molecular Function:
insulin-like growth factor receptor binding
insulin receptor binding
phosphatidylinositol 3-kinase binding
protein kinase C binding
SH2 domain binding
signal transducer activity
transmembrane receptor protein tyrosine kinase adaptor activity
Gene Ontology Cellular Component:
caveola
cytoplasm
cytosol
insulin receptor complex
intracellular membrane-bounded organelle
nucleus
plasma membrane
Keywords:
3D-structure
Complete proteome
Diabetes mellitus
Disease mutation
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Transducer
Ubl conjugation
Interacts With:
P03070; O75815; P04626; P06213; P03495; P11940; P42336; P27986; P27986-2; Q92569; Q06124

Publication

PubMed ID:
8513971 1311924 15489334 8240352 7541045 7559478 7537849 12624099 15364919 15226403 16127460 15592455 17081983 16878150 18952604 18220336 18498745 19369195 19690332 20685959 24275569 8599766 10411883 11694888 8104271 8723689 10206679 10843189 12843189 14671192 12679424 14707024 15590636