Names & Taxonomy
- Uniprot ID:
- P35568
- Entry Name:
- IRS1_HUMAN
- Status:
- reviewed
- Protein Names:
- Insulin receptor substrate 1 (IRS-1)
- Gene Names:
- IRS1
- Gene Names Primary:
- IRS1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1242
- Sequence:
- MASPPESDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAPKRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGHHDGAAALGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLIGIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQVDDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLTRRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHRGSARLHPPLNHSRSIPMPASRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSPSDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGPSTLTAPNGHYILSRGGNGHRCTPGTGLGTSPALAGDEAASAADLDNRFRKRTHSAGTSPTITHQKTPSQSSVASIEEYTEMMPAYPPGGGSGGRLPGHRHSAFVPTRSYPEEGLEMHPLERRGGHHRPDSSTLHTDDGYMPMSPGVAPVPSGRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPNGYMMMSPSGGCSPDIGGGPSSSSSSSNAVPSGTSYGKLWTNGVGGHHSHVLPHPKPPVESSGGKLLPCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEPEEGARHQHLRLSTSSGRLLYAATADDSSSSTSSDSLGGGYCGARLEPSLPHPHHQVLQPHLPRKVDTAAQTNSRLARPTRLSLGDPKASTLPRAREQQQQQQPLLHPPEPKSPGEYVNIEFGSDQSGYLSGPVAFHSSPSVRCPSQLQPAPREEETGTEEYMKMDLGPGRRAAWQESTGVEMGRLGPAPPGAASICRPTRAVPSSRGDYMTMQMSCPRQSYVDTSPAAPVSYADMRTGIAAEEVSLPRATMAAASSSSAASASPTGPQGAAELAAHSSLLGGPQGPGGMSAFTRVNLSPNRNQSAKVIRADPQGCRRRHSSETFSSTPSATRVGNTVPFGAGAAVGGGGGSSSSSEDVKRHSSASFENVWLRPGELGGAPKEPAKLCGAAGGLENGLNYIDLDLVKDFKQCPQECTPEPQPPPPPPPHQPLGSGESSSTRRSSEDLSAYASISFQKQPEDRQ
- Proteomes:
- UP000005640
Function
- Function:
- May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).
- Gene Ontology Go:
- caveola
cytoplasm
cytosol
insulin receptor complex
intracellular membrane-bounded organelle
nucleus
plasma membrane
insulin receptor binding
insulin-like growth factor receptor binding
phosphatidylinositol 3-kinase binding
protein kinase C binding
SH2 domain binding
signal transducer activity
transmembrane receptor protein tyrosine kinase adaptor activity
activation of MAPKK activity
axon guidance
cellular response to insulin stimulus
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
glucose homeostasis
innate immune response
insulin receptor signaling pathway
insulin-like growth factor receptor signaling pathway
JAK-STAT cascade involved in growth hormone signaling pathway
MAPK cascade
negative regulation of insulin receptor signaling pathway
negative regulation of insulin secretion
neurotrophin TRK receptor signaling pathway
phosphatidylinositol 3-kinase signaling
phosphatidylinositol-mediated signaling
positive regulation of cell proliferation
positive regulation of fatty acid beta-oxidation
positive regulation of glucose import
positive regulation of glucose import in response to insulin stimulus
positive regulation of glucose metabolic process
positive regulation of glycogen biosynthetic process
positive regulation of insulin receptor signaling pathway
positive regulation of phosphatidylinositol 3-kinase activity
Ras protein signal transduction
response to insulin
response to peptide hormone
signal transduction
small GTPase mediated signal transduction
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Biological Process:
- activation of MAPKK activity
axon guidance
cellular response to insulin stimulus
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
glucose homeostasis
innate immune response
insulin-like growth factor receptor signaling pathway
insulin receptor signaling pathway
JAK-STAT cascade involved in growth hormone signaling pathway
MAPK cascade
negative regulation of insulin receptor signaling pathway
negative regulation of insulin secretion
neurotrophin TRK receptor signaling pathway
phosphatidylinositol 3-kinase signaling
phosphatidylinositol-mediated signaling
positive regulation of cell proliferation
positive regulation of fatty acid beta-oxidation
positive regulation of glucose import
positive regulation of glucose import in response to insulin stimulus
positive regulation of glucose metabolic process
positive regulation of glycogen biosynthetic process
positive regulation of insulin receptor signaling pathway
positive regulation of phosphatidylinositol 3-kinase activity
Ras protein signal transduction
response to insulin
response to peptide hormone
signal transduction
small GTPase mediated signal transduction
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Molecular Function:
- insulin-like growth factor receptor binding
insulin receptor binding
phosphatidylinositol 3-kinase binding
protein kinase C binding
SH2 domain binding
signal transducer activity
transmembrane receptor protein tyrosine kinase adaptor activity - Gene Ontology Cellular Component:
- caveola
cytoplasm
cytosol
insulin receptor complex
intracellular membrane-bounded organelle
nucleus
plasma membrane - Keywords:
- 3D-structure
Complete proteome
Diabetes mellitus
Disease mutation
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Transducer
Ubl conjugation - Interacts With:
- P03070; O75815; P04626; P06213; P03495; P11940; P42336; P27986; P27986-2; Q92569; Q06124