Names & Taxonomy
- Uniprot ID:
- P35558
- Entry Name:
- PCKGC_HUMAN
- Status:
- reviewed
- Protein Names:
- Phosphoenolpyruvate carboxykinase, cytosolic [GTP] (PEPCK-C) (EC 4.1.1.32)
- Gene Names:
- PCK1 PEPCK1
- Gene Names Primary:
- PCK1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 622
- Sequence:
- MPPQLQNGLNLSAKVVQGSLDSLPQAVREFLENNAELCQPDHIHICDGSEEENGRLLGQMEEEGILRRLKKYDNCWLALTDPRDVARIESKTVIVTQEQRDTVPIPKTGLSQLGRWMSEEDFEKAFNARFPGCMKGRTMYVIPFSMGPLGSPLSKIGIELTDSPYVVASMRIMTRMGTPVLEAVGDGEFVKCLHSVGCPLPLQKPLVNNWPCNPELTLIAHLPDRREIISFGSGYGGNSLLGKKCFALRMASRLAKEEGWLAEHMLILGITNPEGEKKYLAAAFPSACGKTNLAMMNPSLPGWKVECVGDDIAWMKFDAQGHLRAINPENGFFGVAPGTSVKTNPNAIKTIQKNTIFTNVAETSDGGVYWEGIDEPLASGVTITSWKNKEWSSEDGEPCAHPNSRFCTPASQCPIIDAAWESPEGVPIEGIIFGGRRPAGVPLVYEALSWQHGVFVGAAMRSEATAAAEHKGKIIMHDPFAMRPFFGYNFGKYLAHWLSMAQHPAAKLPKIFHVNWFRKDKEGKFLWPGFGENSRVLEWMFNRIDGKASTKLTPIGYIPKEDALNLKGLGHINMMELFSISKEFWEKEVEDIEKYLEDQVNADLPCEIEREILALKQRISQM
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
- Pathway:
- Carbohydrate biosynthesis; gluconeogenesis.
- Catalytic Activity:
- GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO(2).
- Cofactor:
- COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Enzyme Regulation:
- ENZYME REGULATION: Enzyme activity is enhanced by acetylation.
- Active Site:
- ACT_SITE 288 288
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
carboxylic acid binding
GDP binding
GTP binding
magnesium ion binding
manganese ion binding
phosphoenolpyruvate carboxykinase (GTP) activity
carbohydrate metabolic process
cellular response to potassium ion starvation
drug metabolic process
gluconeogenesis
glucose homeostasis
glucose metabolic process
glycerol biosynthetic process from pyruvate
internal protein amino acid acetylation
oxaloacetate metabolic process
positive regulation of transcription from RNA polymerase II promoter in response to acidic pH
response to activity
response to insulin
small molecule metabolic process - Gene Ontology Biological Process:
- carbohydrate metabolic process
cellular response to potassium ion starvation
drug metabolic process
gluconeogenesis
glucose homeostasis
glucose metabolic process
glycerol biosynthetic process from pyruvate
internal protein amino acid acetylation
oxaloacetate metabolic process
positive regulation of transcription from RNA polymerase II promoter in response to acidic pH
response to activity
response to insulin
small molecule metabolic process - Gene Ontology Molecular Function:
- carboxylic acid binding
GDP binding
GTP binding
magnesium ion binding
manganese ion binding
phosphoenolpyruvate carboxykinase (GTP) activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Decarboxylase
GTP-binding
Gluconeogenesis
Lyase
Manganese
Metal-binding
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Ubl conjugation