Names & Taxonomy

Uniprot ID:
P35558
Entry Name:
PCKGC_HUMAN
Status:
reviewed
Protein Names:
Phosphoenolpyruvate carboxykinase, cytosolic [GTP] (PEPCK-C) (EC 4.1.1.32)
Gene Names:
PCK1 PEPCK1
Gene Names Primary:
PCK1
Organism:
Homo sapiens (Human)

Structure

Length:
622
Sequence:
MPPQLQNGLNLSAKVVQGSLDSLPQAVREFLENNAELCQPDHIHICDGSEEENGRLLGQMEEEGILRRLKKYDNCWLALTDPRDVARIESKTVIVTQEQRDTVPIPKTGLSQLGRWMSEEDFEKAFNARFPGCMKGRTMYVIPFSMGPLGSPLSKIGIELTDSPYVVASMRIMTRMGTPVLEAVGDGEFVKCLHSVGCPLPLQKPLVNNWPCNPELTLIAHLPDRREIISFGSGYGGNSLLGKKCFALRMASRLAKEEGWLAEHMLILGITNPEGEKKYLAAAFPSACGKTNLAMMNPSLPGWKVECVGDDIAWMKFDAQGHLRAINPENGFFGVAPGTSVKTNPNAIKTIQKNTIFTNVAETSDGGVYWEGIDEPLASGVTITSWKNKEWSSEDGEPCAHPNSRFCTPASQCPIIDAAWESPEGVPIEGIIFGGRRPAGVPLVYEALSWQHGVFVGAAMRSEATAAAEHKGKIIMHDPFAMRPFFGYNFGKYLAHWLSMAQHPAAKLPKIFHVNWFRKDKEGKFLWPGFGENSRVLEWMFNRIDGKASTKLTPIGYIPKEDALNLKGLGHINMMELFSISKEFWEKEVEDIEKYLEDQVNADLPCEIEREILALKQRISQM
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm.

Function

Function:
Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
Pathway:
Carbohydrate biosynthesis; gluconeogenesis.
Catalytic Activity:
GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO(2).
Cofactor:
COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
Enzyme Regulation:
ENZYME REGULATION: Enzyme activity is enhanced by acetylation.
Active Site:
ACT_SITE 288 288
Gene Ontology Go:
cytoplasm
cytosol
extracellular exosome
carboxylic acid binding
GDP binding
GTP binding
magnesium ion binding
manganese ion binding
phosphoenolpyruvate carboxykinase (GTP) activity
carbohydrate metabolic process
cellular response to potassium ion starvation
drug metabolic process
gluconeogenesis
glucose homeostasis
glucose metabolic process
glycerol biosynthetic process from pyruvate
internal protein amino acid acetylation
oxaloacetate metabolic process
positive regulation of transcription from RNA polymerase II promoter in response to acidic pH
response to activity
response to insulin
small molecule metabolic process
Gene Ontology Biological Process:
carbohydrate metabolic process
cellular response to potassium ion starvation
drug metabolic process
gluconeogenesis
glucose homeostasis
glucose metabolic process
glycerol biosynthetic process from pyruvate
internal protein amino acid acetylation
oxaloacetate metabolic process
positive regulation of transcription from RNA polymerase II promoter in response to acidic pH
response to activity
response to insulin
small molecule metabolic process
Gene Ontology Molecular Function:
carboxylic acid binding
GDP binding
GTP binding
magnesium ion binding
manganese ion binding
phosphoenolpyruvate carboxykinase (GTP) activity
Gene Ontology Cellular Component:
cytoplasm
cytosol
extracellular exosome
Keywords:
3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Decarboxylase
GTP-binding
Gluconeogenesis
Lyase
Manganese
Metal-binding
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Ubl conjugation

Publication

PubMed ID:
8490617 8325643 14702039 11780052 15489334 8547315 1656199 20167786 21726808 24275569 11851336 14552798 17532214