Names & Taxonomy
- Uniprot ID:
- P35504
- Entry Name:
- UD15_HUMAN
- Status:
- reviewed
- Protein Names:
- UDP-glucuronosyltransferase 1-5 (UDPGT 1-5) (UGT1*5) (UGT1-05) (UGT1.5) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-E) (UGT-1E) (UGT1E) (UDP-glucuronosyltransferase 1A5)
- Gene Names:
- UGT1A5 GNT1 UGT1
- Gene Names Primary:
- UGT1A5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 534
- Sequence:
- MATGLQVPLPQLATGLLLLLSVQPWAESGKVLVVPTDGSHWLSMREALRDLHARGHQVVVLTLEVNMYIKEENFFTLTTYAISWTQDEFDRLLLGHTQSFFETEHLLMKFSRRMAIMNNMSLIIHRSCVELLHNEALIRHLHATSFDVVLTDPFHLCAAVLAKYLSIPAVFFLRNIPCDLDFKGTQCPNPSSYIPRLLTTNSDHMTFLQRVKNMLYPLALSYLCHAVSAPYASLASELFQREVSVVDLVSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Microsome. Endoplasmic reticulum membrane
Function
- Function:
- UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity).
- Catalytic Activity:
- UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
- Gene Ontology Go:
- endoplasmic reticulum
integral component of membrane
glucuronosyltransferase activity
flavonoid biosynthetic process
flavonoid glucuronidation
xenobiotic glucuronidation - Gene Ontology Biological Process:
- flavonoid biosynthetic process
flavonoid glucuronidation
xenobiotic glucuronidation - Gene Ontology Molecular Function:
- glucuronosyltransferase activity
- Gene Ontology Cellular Component:
- endoplasmic reticulum
integral component of membrane - Keywords:
- Alternative splicing
Complete proteome
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Membrane
Microsome
Polymorphism
Reference proteome
Signal
Transferase
Transmembrane
Transmembrane helix