Names & Taxonomy
- Uniprot ID:
- P35367
- Entry Name:
- HRH1_HUMAN
- Status:
- reviewed
- Protein Names:
- Histamine H1 receptor (H1R) (HH1R)
- Gene Names:
- HRH1
- Gene Names Primary:
- HRH1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 487
- Sequence:
- MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
- Cross Reference Drug Bank:
- DB01615 DB06766 DB01246 DB00321 DB00543 DB08799 DB01238 DB06216 DB00637 DB00719 DB00972 DB00245 DB04890 DB06698 DB01237 DB00835 DB00354 DB09016 DB00748 DB06016 DB00341 DB08936 DB08800 DB01114 DB00477 DB01239 DB00568 DB00215 DB00283 DB04837 DB00363 DB01176 DB00434 DB01151 DB00967 DB00405 DB00985 DB08801 DB01075 DB01146 DB01142 DB00366 DB01084 DB00751 DB01175 DB00950 DB04841 DB00667 DB00557 DB04946 DB00458 DB08802 DB00920 DB01106 DB06282 DB00455 DB00408 DB00934 DB00737 DB06691 DB01071 DB00902 DB01403 DB06148 DB00370 DB00540 DB00334 DB00768 DB01173 DB01267 DB01619 DB01620 DB00420 DB01069 DB00777 DB01224 DB00734 DB00797 DB00656 DB00726 DB00792 DB00427 DB00246 DB01624
- Gene Ontology Go:
- cytoplasm
integral component of plasma membrane
nucleoplasm
plasma membrane
G-protein coupled receptor activity
histamine receptor activity
cellular response to histamine
eosinophil chemotaxis
G-protein coupled receptor signaling pathway
inflammatory response
inositol phosphate-mediated signaling
memory
modulation of synaptic transmission
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of inositol trisphosphate biosynthetic process
positive regulation of vasoconstriction
regulation of synaptic plasticity
regulation of vascular permeability
regulation of vasoconstriction
visual learning - Gene Ontology Biological Process:
- cellular response to histamine
eosinophil chemotaxis
G-protein coupled receptor signaling pathway
inflammatory response
inositol phosphate-mediated signaling
memory
modulation of synaptic transmission
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of inositol trisphosphate biosynthetic process
positive regulation of vasoconstriction
regulation of synaptic plasticity
regulation of vascular permeability
regulation of vasoconstriction
visual learning - Gene Ontology Molecular Function:
- G-protein coupled receptor activity
histamine receptor activity - Gene Ontology Cellular Component:
- cytoplasm
integral component of plasma membrane
nucleoplasm
plasma membrane - Keywords:
- 3D-structure
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix