Names & Taxonomy
- Uniprot ID:
- P35247
- Entry Name:
- SFTPD_HUMAN
- Status:
- reviewed
- Protein Names:
- Pulmonary surfactant-associated protein D (PSP-D) (SP-D) (Collectin-7) (Lung surfactant protein D)
- Gene Names:
- SFTPD COLEC7 PSPD SFTP4
- Gene Names Primary:
- SFTPD
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 375
- Sequence:
- MLLFLLSALVLLTQPLGYLEAEMKTYSHRTMPSACTLVMCSSVESGLPGRDGRDGREGPRGEKGDPGLPGAAGQAGMPGQAGPVGPKGDNGSVGEPGPKGDTGPSGPPGPPGVPGPAGREGPLGKQGNIGPQGKPGPKGEAGPKGEVGAPGMQGSAGARGLAGPKGERGVPGERGVPGNTGAAGSAGAMGPQGSPGARGPPGLKGDKGIPGDKGAKGESGLPDVASLRQQVEALQGQVQHLQAAFSQYKKVELFPNGQSVGEKIFKTAGFVKPFTEAQLLCTQAGGQLASPRSAAENAALQQLVVAKNEAAFLSMTDSKTEGKFTYPTGESLVYSNWAPGEPNDDGGSEDCVEIFTNGKWNDRACGEKRLVVCEF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film.
Function
- Function:
- Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.
- Gene Ontology Go:
- clathrin-coated endocytic vesicle
collagen trimer
endocytic vesicle
endoplasmic reticulum membrane
extracellular region
extracellular space
lamellar body
lysosome
proteinaceous extracellular matrix
carbohydrate binding
cellular protein metabolic process
defense response to bacterium
innate immune response
lung alveolus development
macrophage chemotaxis
negative regulation of interleukin-2 biosynthetic process
negative regulation of T cell proliferation
positive regulation of phagocytosis
reactive oxygen species metabolic process
receptor-mediated endocytosis
regulation of cytokine production
regulation of immune response
respiratory gaseous exchange
surfactant homeostasis - Gene Ontology Biological Process:
- cellular protein metabolic process
defense response to bacterium
innate immune response
lung alveolus development
macrophage chemotaxis
negative regulation of interleukin-2 biosynthetic process
negative regulation of T cell proliferation
positive regulation of phagocytosis
reactive oxygen species metabolic process
receptor-mediated endocytosis
regulation of cytokine production
regulation of immune response
respiratory gaseous exchange
surfactant homeostasis - Gene Ontology Molecular Function:
- carbohydrate binding
- Gene Ontology Cellular Component:
- clathrin-coated endocytic vesicle
collagen trimer
endocytic vesicle
endoplasmic reticulum membrane
extracellular region
extracellular space
lamellar body
lysosome
proteinaceous extracellular matrix - Keywords:
- 3D-structure
Calcium
Coiled coil
Collagen
Complete proteome
Direct protein sequencing
Disulfide bond
Extracellular matrix
Gaseous exchange
Glycoprotein
Hydroxylation
Immunity
Innate immunity
Lectin
Polymorphism
Reference proteome
Repeat
S-nitrosylation
Secreted
Signal
Surface film