Names & Taxonomy
- Uniprot ID:
- P34995
- Entry Name:
- PE2R1_HUMAN
- Status:
- reviewed
- Protein Names:
- Prostaglandin E2 receptor EP1 subtype (PGE receptor EP1 subtype) (PGE2 receptor EP1 subtype) (Prostanoid EP1 receptor)
- Gene Names:
- PTGER1
- Gene Names Primary:
- PTGER1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 402
- Sequence:
- MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQAAGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVGRYELQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWRRRSRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLRQLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.
- Cross Reference Drug Bank:
- DB00770 DB00905 DB00297 DB00429 DB00917 DB01088
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
prostaglandin E receptor activity
G-protein coupled receptor signaling pathway
response to lipopolysaccharide - Gene Ontology Biological Process:
- G-protein coupled receptor signaling pathway
response to lipopolysaccharide - Gene Ontology Molecular Function:
- prostaglandin E receptor activity
- Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix