Names & Taxonomy
- Uniprot ID:
- P34972
- Entry Name:
- CNR2_HUMAN
- Status:
- reviewed
- Protein Names:
- Cannabinoid receptor 2 (CB-2) (CB2) (hCB2) (CX5)
- Gene Names:
- CNR2 CB2A CB2B
- Gene Names Primary:
- CNR2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 360
- Sequence:
- MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein. Cell projection, dendrite
Function
- Function:
- Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.
- Cross Reference Drug Bank:
- DB00470 DB00486
- Gene Ontology Go:
- dendrite
extrinsic component of cytoplasmic side of plasma membrane
integral component of plasma membrane
perikaryon
plasma membrane
cannabinoid receptor activity
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
immune response
inflammatory response
negative regulation of action potential
negative regulation of inflammatory response
negative regulation of mast cell activation
negative regulation of nitric-oxide synthase activity
negative regulation of synaptic transmission, GABAergic
response to amphetamine
response to lipopolysaccharide
sensory perception of pain - Gene Ontology Biological Process:
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
immune response
inflammatory response
negative regulation of action potential
negative regulation of inflammatory response
negative regulation of mast cell activation
negative regulation of nitric-oxide synthase activity
negative regulation of synaptic transmission, GABAergic
response to amphetamine
response to lipopolysaccharide
sensory perception of pain - Gene Ontology Molecular Function:
- cannabinoid receptor activity
- Gene Ontology Cellular Component:
- dendrite
extrinsic component of cytoplasmic side of plasma membrane
integral component of plasma membrane
perikaryon
plasma membrane - Keywords:
- 3D-structure
Cell membrane
Cell projection
Complete proteome
G-protein coupled receptor
Glycoprotein
Inflammatory response
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix