Names & Taxonomy

Uniprot ID:
P34972
Entry Name:
CNR2_HUMAN
Status:
reviewed
Protein Names:
Cannabinoid receptor 2 (CB-2) (CB2) (hCB2) (CX5)
Gene Names:
CNR2 CB2A CB2B
Gene Names Primary:
CNR2
Organism:
Homo sapiens (Human)

Structure

Length:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Cell projection, dendrite

Function

Function:
Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.
Cross Reference Drug Bank:
DB00470 DB00486
Gene Ontology Go:
dendrite
extrinsic component of cytoplasmic side of plasma membrane
integral component of plasma membrane
perikaryon
plasma membrane
cannabinoid receptor activity
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
immune response
inflammatory response
negative regulation of action potential
negative regulation of inflammatory response
negative regulation of mast cell activation
negative regulation of nitric-oxide synthase activity
negative regulation of synaptic transmission, GABAergic
response to amphetamine
response to lipopolysaccharide
sensory perception of pain
Gene Ontology Biological Process:
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
immune response
inflammatory response
negative regulation of action potential
negative regulation of inflammatory response
negative regulation of mast cell activation
negative regulation of nitric-oxide synthase activity
negative regulation of synaptic transmission, GABAergic
response to amphetamine
response to lipopolysaccharide
sensory perception of pain
Gene Ontology Molecular Function:
cannabinoid receptor activity
Gene Ontology Cellular Component:
dendrite
extrinsic component of cytoplasmic side of plasma membrane
integral component of plasma membrane
perikaryon
plasma membrane
Keywords:
3D-structure
Cell membrane
Cell projection
Complete proteome
G-protein coupled receptor
Glycoprotein
Inflammatory response
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix

Publication

PubMed ID:
7689702 19496827 16710414 15489334 7556170 10400664 10051546 10617657 12153574 12417328 12663043 12711605 12511587 14657172 15266552 18692962 19397896 18286196