Names & Taxonomy
- Uniprot ID:
- P33316
- Entry Name:
- DUT_HUMAN
- Status:
- reviewed
- Protein Names:
- Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
- Gene Names:
- DUT
- Gene Names Primary:
- DUT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 252
- Sequence:
- MTPLCPRPALCYHFLTSLLRSAMQNARGARQRAEAAVLSGPGPPLGRAAQHGIPRPLSSAGRLSQGCRGASTVGAAGWKGELPKAGGSPAPGPETPAISPSKRARPAEVGGMQLRFARLSEHATAPTRGSARAAGYDLYSAYDYTIPPMEKAVVKTDIQIALPSGCYGRVAPRSGLAAKHFIDVGAGVIDEDYRGNVGVVLFNFGKEKFEVKKGDRIAQLICERIFYPEIEEVQALDDTERGSGGFGSTGKN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 2: Nucleus
Function
- Function:
- This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
- Pathway:
- Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.
- Catalytic Activity:
- dUTP + H(2)O = dUMP + diphosphate.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: ; Kinetic parameters: KM=2.5 uM for dUTP
- Enzyme Regulation:
- ENZYME REGULATION: Phosphorylation is necessary for activity.
- Gene Ontology Go:
- extracellular exosome
mitochondrion
nucleoplasm
nucleus
dUTP diphosphatase activity
magnesium ion binding
poly(A) RNA binding
DNA replication
dUMP biosynthetic process
dUTP catabolic process
nucleobase-containing compound metabolic process
nucleobase-containing small molecule metabolic process
pyrimidine nucleobase metabolic process
pyrimidine nucleoside biosynthetic process
small molecule metabolic process - Gene Ontology Biological Process:
- DNA replication
dUMP biosynthetic process
dUTP catabolic process
nucleobase-containing compound metabolic process
nucleobase-containing small molecule metabolic process
pyrimidine nucleobase metabolic process
pyrimidine nucleoside biosynthetic process
small molecule metabolic process - Gene Ontology Molecular Function:
- dUTP diphosphatase activity
magnesium ion binding
poly(A) RNA binding - Gene Ontology Cellular Component:
- extracellular exosome
mitochondrion
nucleoplasm
nucleus - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Direct protein sequencing
Hydrolase
Magnesium
Mitochondrion
Nucleotide metabolism
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Transit peptide - Interacts With:
- Q6ZVK8