Names & Taxonomy

Uniprot ID:
P33316
Entry Name:
DUT_HUMAN
Status:
reviewed
Protein Names:
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
Gene Names:
DUT
Gene Names Primary:
DUT
Organism:
Homo sapiens (Human)

Structure

Length:
252
Sequence:
MTPLCPRPALCYHFLTSLLRSAMQNARGARQRAEAAVLSGPGPPLGRAAQHGIPRPLSSAGRLSQGCRGASTVGAAGWKGELPKAGGSPAPGPETPAISPSKRARPAEVGGMQLRFARLSEHATAPTRGSARAAGYDLYSAYDYTIPPMEKAVVKTDIQIALPSGCYGRVAPRSGLAAKHFIDVGAGVIDEDYRGNVGVVLFNFGKEKFEVKKGDRIAQLICERIFYPEIEEVQALDDTERGSGGFGSTGKN
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Isoform 2: Nucleus

Function

Function:
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
Pathway:
Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.
Catalytic Activity:
dUTP + H(2)O = dUMP + diphosphate.
Cofactor:
COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: ; Kinetic parameters: KM=2.5 uM for dUTP
Enzyme Regulation:
ENZYME REGULATION: Phosphorylation is necessary for activity.
Gene Ontology Go:
extracellular exosome
mitochondrion
nucleoplasm
nucleus
dUTP diphosphatase activity
magnesium ion binding
poly(A) RNA binding
DNA replication
dUMP biosynthetic process
dUTP catabolic process
nucleobase-containing compound metabolic process
nucleobase-containing small molecule metabolic process
pyrimidine nucleobase metabolic process
pyrimidine nucleoside biosynthetic process
small molecule metabolic process
Gene Ontology Biological Process:
DNA replication
dUMP biosynthetic process
dUTP catabolic process
nucleobase-containing compound metabolic process
nucleobase-containing small molecule metabolic process
pyrimidine nucleobase metabolic process
pyrimidine nucleoside biosynthetic process
small molecule metabolic process
Gene Ontology Molecular Function:
dUTP diphosphatase activity
magnesium ion binding
poly(A) RNA binding
Gene Ontology Cellular Component:
extracellular exosome
mitochondrion
nucleoplasm
nucleus
Keywords:
3D-structure
Alternative splicing
Complete proteome
Direct protein sequencing
Hydrolase
Magnesium
Mitochondrion
Nucleotide metabolism
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Transit peptide
Interacts With:
Q6ZVK8

Publication

PubMed ID:
8631816 9070952 9228092 14702039 15489334 1325640 8389461 8631817 17081983 16964243 18669648 20068231 21269460 21406692 24275569 25944712 8805593 17880943