Names & Taxonomy
- Uniprot ID:
- P33261
- Entry Name:
- CP2CJ_HUMAN
- Status:
- reviewed
- Protein Names:
- Cytochrome P450 2C19 (EC 1.14.13.-) ((R)-limonene 6-monooxygenase) (EC 1.14.13.80) ((S)-limonene 6-monooxygenase) (EC 1.14.13.48) ((S)-limonene 7-monooxygenase) (EC 1.14.13.49) (CYPIIC17) (CYPIIC19) (Cytochrome P450-11A) (Cytochrome P450-254C) (Mephenytoin 4-hydroxylase)
- Gene Names:
- CYP2C19
- Gene Names Primary:
- CYP2C19
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 490
- Sequence:
- MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Function
- Function:
- Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
- Catalytic Activity:
- (+)-(R)-limonene + NADPH + O(2) = (+)-trans-carveol + NADP(+) + H(2)O.; (-)-(S)-limonene + NADPH + O(2) = (-)-trans-carveol + NADP(+) + H(2)O.; (-)-(S)-limonene + NADPH + O(2) = (-)-perillyl alcohol + NADP(+) + H(2)O.
- Cofactor:
- COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413;
- Cross Reference Drug Bank:
- DB01418 DB00945 DB00546 DB00918 DB06403 DB00357 DB01424 DB01118 DB00321 DB01060 DB00701 DB01435 DB06605 DB00673 DB01274 DB06413 DB06697 DB00289 DB01076 DB06626 DB00972 DB00245 DB01128 DB04794 DB00188 DB01558 DB00835 DB00297 DB00921 DB00564 DB00748 DB00395 DB00446 DB00672 DB00169 DB01166 DB00501 DB00604 DB00215 DB01211 DB04920 DB00349 DB01242 DB00758 DB01559 DB00257 DB00363 DB00531 DB00091 DB00250 DB00705 DB01151 DB00967 DB01234 DB01191 DB00514 DB00829 DB00586 DB00343 DB01093 DB01075 DB00988 DB00590 DB01142 DB00470 DB00625 DB00216 DB00109 DB08899 DB01175 DB09119 DB00736 DB00783 DB00898 DB00754 DB01628 DB06414 DB00927 DB00949 DB00196 DB01544 DB00472 DB00499 DB01095 DB00176 DB00983 DB01320 DB00317 DB01241 DB01120 DB01296 DB01016 DB01018 DB00502 DB01355 DB06789 DB01050 DB09054 DB01181 DB00619 DB00458 DB00224 DB00328 DB00951 DB09570 DB06738 DB01026 DB00448 DB01259 DB08918 DB01601 DB00455 DB04871 DB00678 DB00227 DB08933 DB01283 DB08932 DB01065 DB01043 DB00371 DB00333 DB00703 DB00763 DB05246 DB00849 DB00264 DB01110 DB01171 DB00745 DB09049 DB00220 DB00622 DB00184 DB00665 DB06712 DB00717 DB00540 DB00334 DB00338 DB04938 DB00776 DB00239 DB06412 DB00213 DB00082 DB00738 DB00312 DB00850 DB00454 DB00780 DB01174 DB00832 DB00252 DB01100 DB01132 DB01621 DB01179 DB06209 DB01058 DB00635 DB00794 DB01032 DB00396 DB01131 DB00420 DB00818 DB00571 DB01589 DB01224 DB00468 DB01129 DB00980 DB00863 DB08896 DB01045 DB08864 DB00503 DB00412 DB01098 DB01232 DB01037 DB01104 DB00203 DB00641 DB06268 DB00398 DB00259 DB00675 DB06204 DB00966 DB00231 DB00444 DB00857 DB00624 DB01041 DB00679 DB00208 DB00373 DB01007 DB00932 DB08895 DB01124 DB01036 DB00273 DB00214 DB05109 DB00752 DB00347 DB00726 DB01361 DB00313 DB00285 DB00661 DB08828 DB00582 DB09068 DB00682 DB00549 DB00495 DB00425 DB00909
- Gene Ontology Go:
- endoplasmic reticulum membrane
intracellular membrane-bounded organelle
(R)-limonene 6-monooxygenase activity
(S)-limonene 6-monooxygenase activity
(S)-limonene 7-monooxygenase activity
arachidonic acid epoxygenase activity
enzyme binding
heme binding
iron ion binding
monooxygenase activity
oxidoreductase activity
oxygen binding
steroid hydroxylase activity
arachidonic acid metabolic process
drug metabolic process
epoxygenase P450 pathway
exogenous drug catabolic process
heterocycle metabolic process
monoterpenoid metabolic process
omega-hydroxylase P450 pathway
oxidation-reduction process
small molecule metabolic process
steroid metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- arachidonic acid metabolic process
drug metabolic process
epoxygenase P450 pathway
exogenous drug catabolic process
heterocycle metabolic process
monoterpenoid metabolic process
omega-hydroxylase P450 pathway
oxidation-reduction process
small molecule metabolic process
steroid metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- (R)-limonene 6-monooxygenase activity
(S)-limonene 6-monooxygenase activity
(S)-limonene 7-monooxygenase activity
arachidonic acid epoxygenase activity
enzyme binding
heme binding
iron ion binding
monooxygenase activity
oxidoreductase activity
oxygen binding
steroid hydroxylase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
intracellular membrane-bounded organelle - Keywords:
- 3D-structure
Acetylation
Complete proteome
Direct protein sequencing
Endoplasmic reticulum
Heme
Iron
Membrane
Metal-binding
Microsome
Monooxygenase
NADP
Oxidoreductase
Polymorphism
Reference proteome