Names & Taxonomy
- Uniprot ID:
- P33032
- Entry Name:
- MC5R_HUMAN
- Status:
- reviewed
- Protein Names:
- Melanocortin receptor 5 (MC5-R) (MC-2)
- Gene Names:
- MC5R
- Gene Names Primary:
- MC5R
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 325
- Sequence:
- MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGFRIACSFPRRD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
hormone binding
melanocortin receptor activity
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
positive regulation of cAMP biosynthetic process - Gene Ontology Biological Process:
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
positive regulation of cAMP biosynthetic process - Gene Ontology Molecular Function:
- hormone binding
melanocortin receptor activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- Cell membrane
Complete proteome
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Palmitate
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix