Names & Taxonomy
- Uniprot ID:
- P32927
- Entry Name:
- IL3RB_HUMAN
- Status:
- reviewed
- Protein Names:
- Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131)
- Gene Names:
- CSF2RB IL3RB IL5RB
- Gene Names Primary:
- CSF2RB
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 897
- Sequence:
- MVLAQGLLSMALLALCWERSLAGAEETIPLQTLRCYNDYTSHITCRWADTQDAQRLVNVTLIRRVNEDLLEPVSCDLSDDMPWSACPHPRCVPRRCVIPCQSFVVTDVDYFSFQPDRPLGTRLTVTLTQHVQPPEPRDLQISTDQDHFLLTWSVALGSPQSHWLSPGDLEFEVVYKRLQDSWEDAAILLSNTSQATLGPEHLMPSSTYVARVRTRLAPGSRLSGRPSKWSPEVCWDSQPGDEAQPQNLECFFDGAAVLSCSWEVRKEVASSVSFGLFYKPSPDAGEEECSPVLREGLGSLHTRHHCQIPVPDPATHGQYIVSVQPRRAEKHIKSSVNIQMAPPSLNVTKDGDSYSLRWETMKMRYEHIDHTFEIQYRKDTATWKDSKTETLQNAHSMALPALEPSTRYWARVRVRTSRTGYNGIWSEWSEARSWDTESVLPMWVLALIVIFLTIAVLLALRFCGIYGYRLRRKWEEKIPNPSKSHLFQNGSAELWPPGSMSAFTSGSPPHQGPWGSRFPELEGVFPVGFGDSEVSPLTIEDPKHVCDPPSGPDTTPAASDLPTEQPPSPQPGPPAASHTPEKQASSFDFNGPYLGPPHSRSLPDILGQPEPPQEGGSQKSPPPGSLEYLCLPAGGQVQLVPLAQAMGPGQAVEVERRPSQGAAGSPSLESGGGPAPPALGPRVGGQDQKDSPVAIPMSSGDTEDPGVASGYVSSADLVFTPNSGASSVSLVPSLGLPSDQTPSLCPGLASGPPGAPGPVKSGFEGYVELPPIEGRSPRSPRNNPVPPEAKSPVLNPGERPADVSPTSPQPEGLLVLQQVGDYCFLPGLGPGPLSLRSKPSSPGPGPEIKNLDQAFQVKKPPGQAVPQVPVIQLFKALKQQDYLSLPPWEVNKPGEVC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.
- Cross Reference Drug Bank:
- DB00020
- Gene Ontology Go:
- granulocyte macrophage colony-stimulating factor receptor complex
integral component of plasma membrane
intracellular
plasma membrane
cytokine receptor activity
receptor activity
activation of MAPKK activity
axon guidance
cellular protein metabolic process
cellular response to interleukin-3
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
insulin receptor signaling pathway
interleukin-3-mediated signaling pathway
interleukin-5-mediated signaling pathway
MAPK cascade
neurotrophin TRK receptor signaling pathway
Ras protein signal transduction
respiratory gaseous exchange
signal transduction
small GTPase mediated signal transduction
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Biological Process:
- activation of MAPKK activity
axon guidance
cellular protein metabolic process
cellular response to interleukin-3
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
insulin receptor signaling pathway
interleukin-3-mediated signaling pathway
interleukin-5-mediated signaling pathway
MAPK cascade
neurotrophin TRK receptor signaling pathway
Ras protein signal transduction
respiratory gaseous exchange
signal transduction
small GTPase mediated signal transduction
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Molecular Function:
- cytokine receptor activity
receptor activity - Gene Ontology Cellular Component:
- granulocyte macrophage colony-stimulating factor receptor complex
integral component of plasma membrane
intracellular
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Disulfide bond
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix - Interacts With:
- P04141; P05113; P05556; O60674