Names & Taxonomy
- Uniprot ID:
- P32754
- Entry Name:
- HPPD_HUMAN
- Status:
- reviewed
- Protein Names:
- 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) (4-hydroxyphenylpyruvic acid oxidase) (4HPPD) (HPD) (HPPDase)
- Gene Names:
- HPD PPD
- Gene Names Primary:
- HPD
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 393
- Sequence:
- MTTYSDKGAKPERGRFLHFHSVTFWVGNAKQAASFYCSKMGFEPLAYRGLETGSREVVSHVIKQGKIVFVLSSALNPWNKEMGDHLVKHGDGVKDIAFEVEDCDYIVQKARERGAKIMREPWVEQDKFGKVKFAVLQTYGDTTHTLVEKMNYIGQFLPGYEAPAFMDPLLPKLPKCSLEMIDHIVGNQPDQEMVSASEWYLKNLQFHRFWSVDDTQVHTEYSSLRSIVVANYEESIKMPINEPAPGKKKSQIQEYVDYNGGAGVQHIALKTEDIITAIRHLRERGLEFLSVPSTYYKQLREKLKTAKIKVKENIDALEELKILVDYDEKGYLLQIFTKPVQDRPTLFLEVIQRHNHQGFGAGNFNSLFKAFEEEQNLRGNLTNMETNGVVPGM
- Proteomes:
- UP000005640
Function
- Function:
- Key enzyme in the degradation of tyrosine.
- Pathway:
- Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.
- Catalytic Activity:
- 4-hydroxyphenylpyruvate + O(2) = homogentisate + CO(2).
- Cofactor:
- COFACTOR: Name=Fe cation; Xref=ChEBI:CHEBI:24875;
- Cross Reference Drug Bank:
- DB00348
- Gene Ontology Go:
- cytosol
extracellular exosome
4-hydroxyphenylpyruvate dioxygenase activity
metal ion binding
cellular nitrogen compound metabolic process
L-phenylalanine catabolic process
small molecule metabolic process
tyrosine catabolic process - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
L-phenylalanine catabolic process
small molecule metabolic process
tyrosine catabolic process - Gene Ontology Molecular Function:
- 4-hydroxyphenylpyruvate dioxygenase activity
metal ion binding - Gene Ontology Cellular Component:
- cytosol
extracellular exosome - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Dioxygenase
Disease mutation
Iron
Mental retardation
Metal-binding
Oxidoreductase
Phenylalanine catabolism
Phosphoprotein
Polymorphism
Reference proteome
Tyrosine catabolism