Names & Taxonomy
- Uniprot ID:
- P32745
- Entry Name:
- SSR3_HUMAN
- Status:
- reviewed
- Protein Names:
- Somatostatin receptor type 3 (SS-3-R) (SS3-R) (SS3R) (SSR-28)
- Gene Names:
- SSTR3
- Gene Names Primary:
- SSTR3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 418
- Sequence:
- MDMLHPSSVSTTSEPENASSAWPPDATLGNVSAGPSPAGLAVSGVLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRVLLRPSRRVRSQEPTVGPPEKTEEEDEEEEDGEESREGGKGKEMNGRVSQITQPGTSGQERPPSRVASKEQQLLPQEASTGEKSSTMRISYL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.
- Cross Reference Drug Bank:
- DB06663
- Gene Ontology Go:
- ciliary membrane
cytoplasm
integral component of plasma membrane
neuron projection
nonmotile primary cilium
plasma membrane
neuropeptide binding
somatostatin receptor activity
cell-cell signaling
cellular response to estradiol stimulus
cellular response to glucocorticoid stimulus
cerebellum development
forebrain development
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
hormone-mediated apoptotic signaling pathway
negative regulation of cell proliferation
organelle organization
response to starvation
somatostatin signaling pathway
spermatogenesis - Gene Ontology Biological Process:
- cell-cell signaling
cellular response to estradiol stimulus
cellular response to glucocorticoid stimulus
cerebellum development
forebrain development
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
hormone-mediated apoptotic signaling pathway
negative regulation of cell proliferation
organelle organization
response to starvation
somatostatin signaling pathway
spermatogenesis - Gene Ontology Molecular Function:
- neuropeptide binding
somatostatin receptor activity - Gene Ontology Cellular Component:
- ciliary membrane
cytoplasm
integral component of plasma membrane
neuron projection
nonmotile primary cilium
plasma membrane - Keywords:
- Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix - Interacts With:
- O75970; O55164; P30874