Names & Taxonomy
- Uniprot ID:
- P32297
- Entry Name:
- ACHA3_HUMAN
- Status:
- reviewed
- Protein Names:
- Neuronal acetylcholine receptor subunit alpha-3
- Gene Names:
- CHRNA3 NACHRA3
- Gene Names Primary:
- CHRNA3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 505
- Sequence:
- MGSGPLSLPLALSPPRLLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPTSNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFLQPLMAREDA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Function
- Function:
- After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
- Cross Reference Drug Bank:
- DB01156 DB09028 DB00514 DB00898 DB00674 DB01227 DB00184 DB01090 DB01273
- Gene Ontology Go:
- acetylcholine-gated channel complex
cell junction
dendrite
integral component of membrane
neuronal cell body
plasma membrane
postsynaptic density
postsynaptic membrane
acetylcholine binding
acetylcholine receptor activity
acetylcholine-activated cation-selective channel activity
drug binding
ligand-gated ion channel activity
activation of transmembrane receptor protein tyrosine kinase activity
behavioral response to nicotine
excitatory postsynaptic potential
heart development
ion transport
locomotory behavior
nervous system development
protein heterooligomerization
regulation of acetylcholine secretion, neurotransmission
regulation of dendrite morphogenesis
regulation of membrane potential
regulation of smooth muscle contraction
response to drug
response to inorganic substance
signal transduction
synaptic transmission
synaptic transmission involved in micturition
synaptic transmission, cholinergic - Gene Ontology Biological Process:
- activation of transmembrane receptor protein tyrosine kinase activity
behavioral response to nicotine
excitatory postsynaptic potential
heart development
ion transport
locomotory behavior
nervous system development
protein heterooligomerization
regulation of acetylcholine secretion, neurotransmission
regulation of dendrite morphogenesis
regulation of membrane potential
regulation of smooth muscle contraction
response to drug
response to inorganic substance
signal transduction
synaptic transmission
synaptic transmission, cholinergic
synaptic transmission involved in micturition - Gene Ontology Molecular Function:
- acetylcholine-activated cation-selective channel activity
acetylcholine binding
acetylcholine receptor activity
drug binding
ligand-gated ion channel activity - Gene Ontology Cellular Component:
- acetylcholine-gated channel complex
cell junction
dendrite
integral component of membrane
neuronal cell body
plasma membrane
postsynaptic density
postsynaptic membrane - Keywords:
- 3D-structure
Alternative splicing
Cell junction
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Phosphoprotein
Polymorphism
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport