Names & Taxonomy
- Uniprot ID:
- P31995
- Entry Name:
- FCG2C_HUMAN
- Status:
- reviewed
- Protein Names:
- Low affinity immunoglobulin gamma Fc region receptor II-c (IgG Fc receptor II-c) (CDw32) (Fc-gamma RII-c) (Fc-gamma-RIIc) (FcRII-c) (CD antigen CD32)
- Gene Names:
- FCGR2C CD32 FCG2 IGFR2
- Gene Names Primary:
- FCGR2C
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 323
- Sequence:
- MGILSFLPVLATESDWADCKSPQPWGHMLLWTAVLFLAPVAGTPAAPPKAVLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHNGNLIPTHTQPSYRFKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQNGKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIGYTLYSSKPVTITVQAPSSSPMGIIVAVVTGIAVAAIVAAVVALIYCRKKRISANSTDPVKAAQFEPPGRQMIAIRKRQPEETNNDYETADGGYMTLNPRAPTDDDKNIYLTLPPNDHVNSNN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform IIC4: Cytoplasm
Function
- Function:
- Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells.
- Cross Reference Drug Bank:
- DB00054 DB00051 DB00092 DB00087 DB00074 DB00112 DB00002 DB00111 DB00095 DB00005 DB00056 DB00078 DB00028 DB00075 DB00108 DB00110 DB00073 DB00081 DB00072
- Gene Ontology Go:
- cytoplasm
integral component of membrane
plasma membrane
transmembrane signaling receptor activity
immune response
signal transduction - Gene Ontology Biological Process:
- immune response
signal transduction - Gene Ontology Molecular Function:
- transmembrane signaling receptor activity
- Gene Ontology Cellular Component:
- cytoplasm
integral component of membrane
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Complete proteome
Cytoplasm
Disulfide bond
Glycoprotein
IgG-binding protein
Immunoglobulin domain
Membrane
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix - Interacts With:
- P02741; P16333