Names & Taxonomy

Uniprot ID:
P31639
Entry Name:
SC5A2_HUMAN
Status:
reviewed
Protein Names:
Sodium/glucose cotransporter 2 (Na(+)/glucose cotransporter 2) (Low affinity sodium-glucose cotransporter) (Solute carrier family 5 member 2)
Gene Names:
SLC5A2 SGLT2
Gene Names Primary:
SLC5A2
Organism:
Homo sapiens (Human)

Structure

Length:
672
Sequence:
MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFAPVYLTAGVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSLTVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQRCLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVGCSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDRELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRVNEQGAFWGLIGGLLMGLARLIPEFSFGSGSCVQPSACPAFLCGVHYLYFAIVLFFCSGLLTLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDADEQQGSSLPVQNGCPESAMEMNEPQAPAPSLFRQCLLWFCGMSRGGVGSPPPLTQEEAAAAARRLEDISEDPSWARVVNLNALLMMAVAVFLWGFYA
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Multi-pass membrane protein.

Function

Function:
Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1.; Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.
Cross Reference Drug Bank:
DB08907 DB06292 DB09038
Gene Ontology Go:
brush border membrane
extracellular exosome
integral component of membrane
plasma membrane
low-affinity glucose:sodium symporter activity
carbohydrate metabolic process
transmembrane transport
transport
Gene Ontology Biological Process:
carbohydrate metabolic process
transmembrane transport
transport
Gene Ontology Molecular Function:
low-affinity glucose:sodium symporter activity
Gene Ontology Cellular Component:
brush border membrane
extracellular exosome
integral component of membrane
plasma membrane
Keywords:
Alternative splicing
Complete proteome
Disease mutation
Glycoprotein
Ion transport
Membrane
Reference proteome
Sodium
Sodium transport
Sugar transport
Symport
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
1415574 15616553 15489334 14614622