Names & Taxonomy
- Uniprot ID:
- P31639
- Entry Name:
- SC5A2_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium/glucose cotransporter 2 (Na(+)/glucose cotransporter 2) (Low affinity sodium-glucose cotransporter) (Solute carrier family 5 member 2)
- Gene Names:
- SLC5A2 SGLT2
- Gene Names Primary:
- SLC5A2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 672
- Sequence:
- MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFAPVYLTAGVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSLTVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQRCLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVGCSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDRELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRVNEQGAFWGLIGGLLMGLARLIPEFSFGSGSCVQPSACPAFLCGVHYLYFAIVLFFCSGLLTLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDADEQQGSSLPVQNGCPESAMEMNEPQAPAPSLFRQCLLWFCGMSRGGVGSPPPLTQEEAAAAARRLEDISEDPSWARVVNLNALLMMAVAVFLWGFYA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1.; Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.
- Cross Reference Drug Bank:
- DB08907 DB06292 DB09038
- Gene Ontology Go:
- brush border membrane
extracellular exosome
integral component of membrane
plasma membrane
low-affinity glucose:sodium symporter activity
carbohydrate metabolic process
transmembrane transport
transport - Gene Ontology Biological Process:
- carbohydrate metabolic process
transmembrane transport
transport - Gene Ontology Molecular Function:
- low-affinity glucose:sodium symporter activity
- Gene Ontology Cellular Component:
- brush border membrane
extracellular exosome
integral component of membrane
plasma membrane - Keywords:
- Alternative splicing
Complete proteome
Disease mutation
Glycoprotein
Ion transport
Membrane
Reference proteome
Sodium
Sodium transport
Sugar transport
Symport
Transmembrane
Transmembrane helix
Transport