Names & Taxonomy
- Uniprot ID:
- P31213
- Entry Name:
- S5A2_HUMAN
- Status:
- reviewed
- Protein Names:
- 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (EC 1.3.1.22) (5 alpha-SR2) (SR type 2) (Steroid 5-alpha-reductase 2) (S5AR 2) (Type II 5-alpha reductase)
- Gene Names:
- SRD5A2
- Gene Names Primary:
- SRD5A2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 254
- Sequence:
- MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPSFAVPAGILARQPLSLFGPPGTVLLGLFCVHYFHRTFVYSLLNRGRPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIPQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane
Function
- Function:
- Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
- Catalytic Activity:
- A 3-oxo-5-alpha-steroid + NADP(+) = a 3-oxo-Delta(4)-steroid + NADPH.
- Cross Reference Drug Bank:
- DB00548 DB01126 DB01216 DB00421
- Gene Ontology Go:
- cell body fiber
endoplasmic reticulum membrane
integral component of membrane
neuronal cell body
3-oxo-5-alpha-steroid 4-dehydrogenase activity
amide binding
cholestenone 5-alpha-reductase activity
sterol 5-alpha reductase activity
androgen biosynthetic process
androgen metabolic process
biphenyl metabolic process
bone development
cell differentiation
cell-cell signaling
dibenzo-p-dioxin metabolic process
female genitalia development
hippocampus development
hypothalamus development
male genitalia development
male gonad development
phthalate metabolic process
response to drug
response to follicle-stimulating hormone
response to nutrient levels
response to peptide hormone
response to testosterone
small molecule metabolic process
steroid catabolic process
steroid metabolic process - Gene Ontology Biological Process:
- androgen biosynthetic process
androgen metabolic process
biphenyl metabolic process
bone development
cell-cell signaling
cell differentiation
dibenzo-p-dioxin metabolic process
female genitalia development
hippocampus development
hypothalamus development
male genitalia development
male gonad development
phthalate metabolic process
response to drug
response to follicle-stimulating hormone
response to nutrient levels
response to peptide hormone
response to testosterone
small molecule metabolic process
steroid catabolic process
steroid metabolic process - Gene Ontology Molecular Function:
- 3-oxo-5-alpha-steroid 4-dehydrogenase activity
amide binding
cholestenone 5-alpha-reductase activity
sterol 5-alpha reductase activity - Gene Ontology Cellular Component:
- cell body fiber
endoplasmic reticulum membrane
integral component of membrane
neuronal cell body - Keywords:
- Complete proteome
Differentiation
Disease mutation
Endoplasmic reticulum
Membrane
Microsome
NADP
Oxidoreductase
Polymorphism
Pseudohermaphroditism
Reference proteome
Sexual differentiation
Transmembrane
Transmembrane helix