Names & Taxonomy
- Uniprot ID:
- P31040
- Entry Name:
- SDHA_HUMAN
- Status:
- reviewed
- Protein Names:
- Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC 1.3.5.1) (Flavoprotein subunit of complex II) (Fp)
- Gene Names:
- SDHA SDH2 SDHF
- Gene Names Primary:
- SDHA
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 664
- Sequence:
- MSGVRGLSRLLSARRLALAKAWPTVLQTGTRGFHFTVDGNKRASAKVSDSISAQYPVVDHEFDAVVVGAGGAGLRAAFGLSEAGFNTACVTKLFPTRSHTVAAQGGINAALGNMEEDNWRWHFYDTVKGSDWLGDQDAIHYMTEQAPAAVVELENYGMPFSRTEDGKIYQRAFGGQSLKFGKGGQAHRCCCVADRTGHSLLHTLYGRSLRYDTSYFVEYFALDLLMENGECRGVIALCIEDGSIHRIRAKNTVVATGGYGRTYFSCTSAHTSTGDGTAMITRAGLPCQDLEFVQFHPTGIYGAGCLITEGCRGEGGILINSQGERFMERYAPVAKDLASRDVVSRSMTLEIREGRGCGPEKDHVYLQLHHLPPEQLATRLPGISETAMIFAGVDVTKEPIPVLPTVHYNMGGIPTNYKGQVLRHVNGQDQIVPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIEESCRPGDKVPPIKPNAGEESVMNLDKLRFADGSIRTSELRLSMQKSMQNHAAVFRVGSVLQEGCGKISKLYGDLKHLKTFDRGMVWNTDLVETLELQNLMLCALQTIYGAEARKESRGAHAREDYKVRIDEYDYSKPIQGQQKKPFEEHWRKHTLSYVDVGTGKVTLEYRPVIDKTLNEADCATVPPAIRSY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion inner membrane
Function
- Function:
- Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed:24781757). Can act as a tumor suppressor (PubMed:20484225).
- Pathway:
- Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.
- Catalytic Activity:
- Succinate + a quinone = fumarate + a quinol.
- Cofactor:
- COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692;
- Active Site:
- ACT_SITE 340 340 Proton acceptor.
- Cross Reference Drug Bank:
- DB00139
- Gene Ontology Go:
- mitochondrial inner membrane
mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)
mitochondrion
myelin sheath
flavin adenine dinucleotide binding
succinate dehydrogenase (ubiquinone) activity
cellular metabolic process
nervous system development
oxidation-reduction process
respiratory electron transport chain
small molecule metabolic process
succinate metabolic process
tricarboxylic acid cycle - Gene Ontology Biological Process:
- cellular metabolic process
nervous system development
oxidation-reduction process
respiratory electron transport chain
small molecule metabolic process
succinate metabolic process
tricarboxylic acid cycle - Gene Ontology Molecular Function:
- flavin adenine dinucleotide binding
succinate dehydrogenase (ubiquinone) activity - Gene Ontology Cellular Component:
- mitochondrial inner membrane
mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)
mitochondrion
myelin sheath - Keywords:
- Acetylation
Alternative splicing
Cardiomyopathy
Complete proteome
Direct protein sequencing
Disease mutation
Electron transport
FAD
Flavoprotein
Leigh syndrome
Membrane
Mitochondrion
Mitochondrion inner membrane
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome
Transit peptide
Transport
Tricarboxylic acid cycle
Tumor suppressor - Interacts With:
- P21912