Names & Taxonomy
- Uniprot ID:
- P30926
- Entry Name:
- ACHB4_HUMAN
- Status:
- reviewed
- Protein Names:
- Neuronal acetylcholine receptor subunit beta-4
- Gene Names:
- CHRNB4
- Gene Names Primary:
- CHRNB4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 498
- Sequence:
- MRRAPSLVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAFPPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRFRQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLPPLFQTHAASEGPYAAQRD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Function
- Function:
- After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
- Cross Reference Drug Bank:
- DB00514 DB00898 DB00674 DB01227 DB00184 DB01090
- Gene Ontology Go:
- acetylcholine-gated channel complex
cell junction
integral component of membrane
integral component of plasma membrane
neuron projection
plasma membrane
postsynaptic membrane
acetylcholine binding
acetylcholine receptor activity
acetylcholine-activated cation-selective channel activity
drug binding
ligand-gated ion channel activity
action potential
behavioral response to nicotine
cation transmembrane transport
chemical synaptic transmission, postsynaptic
ion transmembrane transport
ion transport
locomotory behavior
positive regulation of transmission of nerve impulse
protein heterooligomerization
regulation of neurotransmitter secretion
regulation of smooth muscle contraction
response to nicotine
signal transduction
smooth muscle contraction
synaptic transmission
synaptic transmission involved in micturition
synaptic transmission, cholinergic - Gene Ontology Biological Process:
- action potential
behavioral response to nicotine
cation transmembrane transport
chemical synaptic transmission, postsynaptic
ion transmembrane transport
ion transport
locomotory behavior
positive regulation of transmission of nerve impulse
protein heterooligomerization
regulation of neurotransmitter secretion
regulation of smooth muscle contraction
response to nicotine
signal transduction
smooth muscle contraction
synaptic transmission
synaptic transmission, cholinergic
synaptic transmission involved in micturition - Gene Ontology Molecular Function:
- acetylcholine-activated cation-selective channel activity
acetylcholine binding
acetylcholine receptor activity
drug binding
ligand-gated ion channel activity - Gene Ontology Cellular Component:
- acetylcholine-gated channel complex
cell junction
integral component of membrane
integral component of plasma membrane
neuron projection
plasma membrane
postsynaptic membrane - Keywords:
- 3D-structure
Alternative splicing
Cell junction
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Polymorphism
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport