Names & Taxonomy
- Uniprot ID:
- P30711
- Entry Name:
- GSTT1_HUMAN
- Status:
- reviewed
- Protein Names:
- Glutathione S-transferase theta-1 (EC 2.5.1.18) (GST class-theta-1) (Glutathione transferase T1-1)
- Gene Names:
- GSTT1
- Gene Names Primary:
- GSTT1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 240
- Sequence:
- MGLELYLDLLSQPCRAVYIFAKKNDIPFELRIVDLIKGQHLSDAFAQVNPLKKVPALKDGDFTLTESVAILLYLTRKYKVPDYWYPQDLQARARVDEYLAWQHTTLRRSCLRALWHKVMFPVFLGEPVSPQTLAATLAELDVTLQLLEDKFLQNKAFLTGPHISLADLVAITELMHPVGAGCQVFEGRPKLATWRQRVEAAVGEDLFQEAHEVILKAKDFPPADPTIKQKLMPWVLAMIR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide.
- Catalytic Activity:
- RX + glutathione = HX + R-S-glutathione.
- Cross Reference Drug Bank:
- DB00958 DB00515 DB00773 DB00143 DB00526
- Gene Ontology Go:
- cytosol
extracellular exosome
glutathione peroxidase activity
glutathione transferase activity
cellular oxidant detoxification
glutathione derivative biosynthetic process
glutathione metabolic process
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- cellular oxidant detoxification
glutathione derivative biosynthetic process
glutathione metabolic process
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- glutathione peroxidase activity
glutathione transferase activity - Gene Ontology Cellular Component:
- cytosol
extracellular exosome - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Polymorphism
Reference proteome
Transferase