Names & Taxonomy
- Uniprot ID:
- P30556
- Entry Name:
- AGTR1_HUMAN
- Status:
- reviewed
- Protein Names:
- Type-1 angiotensin II receptor (AT1AR) (AT1BR) (Angiotensin II type-1 receptor) (AT1)
- Gene Names:
- AGTR1 AGTR1A AGTR1B AT2R1 AT2R1B
- Gene Names Primary:
- AGTR1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 359
- Sequence:
- MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
- Cross Reference Drug Bank:
- DB08822 DB00796 DB00876 DB01342 DB01029 DB00678 DB00275 DB01347 DB01349 DB00966 DB00177
- Gene Ontology Go:
- integral component of membrane
integral component of plasma membrane
intracellular
plasma membrane
angiotensin type I receptor activity
angiotensin type II receptor activity
bradykinin receptor binding
protein heterodimerization activity
angiotensin-activated signaling pathway
calcium-mediated signaling
cell chemotaxis
G-protein coupled receptor signaling pathway
kidney development
low-density lipoprotein particle remodeling
phospholipase C-activating angiotensin-activated signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cellular protein metabolic process
positive regulation of cholesterol esterification
positive regulation of cytosolic calcium ion concentration
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
positive regulation of inflammatory response
positive regulation of macrophage derived foam cell differentiation
positive regulation of NAD(P)H oxidase activity
positive regulation of phospholipase A2 activity
positive regulation of reactive oxygen species metabolic process
regulation of blood vessel size by renin-angiotensin
regulation of cell growth
regulation of cell proliferation
regulation of inflammatory response
regulation of renal sodium excretion
regulation of systemic arterial blood pressure by renin-angiotensin
regulation of vasoconstriction
regulation of vasodilation
renin-angiotensin regulation of aldosterone production
Rho protein signal transduction - Gene Ontology Biological Process:
- angiotensin-activated signaling pathway
calcium-mediated signaling
cell chemotaxis
G-protein coupled receptor signaling pathway
kidney development
low-density lipoprotein particle remodeling
phospholipase C-activating angiotensin-activated signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cellular protein metabolic process
positive regulation of cholesterol esterification
positive regulation of cytosolic calcium ion concentration
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
positive regulation of inflammatory response
positive regulation of macrophage derived foam cell differentiation
positive regulation of NAD(P)H oxidase activity
positive regulation of phospholipase A2 activity
positive regulation of reactive oxygen species metabolic process
regulation of blood vessel size by renin-angiotensin
regulation of cell growth
regulation of cell proliferation
regulation of inflammatory response
regulation of renal sodium excretion
regulation of systemic arterial blood pressure by renin-angiotensin
regulation of vasoconstriction
regulation of vasodilation
renin-angiotensin regulation of aldosterone production
Rho protein signal transduction - Gene Ontology Molecular Function:
- angiotensin type II receptor activity
angiotensin type I receptor activity
bradykinin receptor binding
protein heterodimerization activity - Gene Ontology Cellular Component:
- integral component of membrane
integral component of plasma membrane
intracellular
plasma membrane - Keywords:
- 3D-structure
Cell membrane
Complete proteome
Disease mutation
Disulfide bond
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Palmitate
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix - Interacts With:
- P01019