Names & Taxonomy
- Uniprot ID:
- P30153
- Entry Name:
- 2AAA_HUMAN
- Status:
- reviewed
- Protein Names:
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (Medium tumor antigen-associated 61 kDa protein) (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha)
- Gene Names:
- PPP2R1A
- Gene Names Primary:
- PPP2R1A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 589
- Sequence:
- MAAADGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYDEDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHSPSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPMVRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCENLSADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNVAKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEALTVLSLA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis.
- Gene Ontology Go:
- chromosome, centromeric region
cytosol
extracellular exosome
membrane
microtubule cytoskeleton
mitochondrion
nucleus
protein phosphatase type 2A complex
antigen binding
protein heterodimerization activity
protein phosphatase type 2A regulator activity
protein serine/threonine phosphatase activity
apoptotic process
ceramide metabolic process
chromosome segregation
female meiotic division
fibroblast growth factor receptor signaling pathway
G2/M transition of mitotic cell cycle
gene expression
inactivation of MAPK activity
meiotic sister chromatid cohesion, centromeric
meiotic spindle elongation
mitotic cell cycle
mitotic nuclear envelope reassembly
mitotic sister chromatid separation
negative regulation of cell growth
negative regulation of tyrosine phosphorylation of Stat3 protein
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
organelle organization
peptidyl-serine dephosphorylation
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
protein complex assembly
protein dephosphorylation
regulation of cell adhesion
regulation of cell differentiation
regulation of DNA replication
regulation of growth
regulation of meiotic cell cycle process involved in oocyte maturation
regulation of protein phosphatase type 2A activity
regulation of transcription, DNA-templated
regulation of Wnt signaling pathway
response to organic substance
RNA splicing
second-messenger-mediated signaling - Gene Ontology Biological Process:
- apoptotic process
ceramide metabolic process
chromosome segregation
female meiotic division
fibroblast growth factor receptor signaling pathway
G2/M transition of mitotic cell cycle
gene expression
inactivation of MAPK activity
meiotic sister chromatid cohesion, centromeric
meiotic spindle elongation
mitotic cell cycle
mitotic nuclear envelope reassembly
mitotic sister chromatid separation
negative regulation of cell growth
negative regulation of tyrosine phosphorylation of Stat3 protein
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
organelle organization
peptidyl-serine dephosphorylation
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
protein complex assembly
protein dephosphorylation
regulation of cell adhesion
regulation of cell differentiation
regulation of DNA replication
regulation of growth
regulation of meiotic cell cycle process involved in oocyte maturation
regulation of protein phosphatase type 2A activity
regulation of transcription, DNA-templated
regulation of Wnt signaling pathway
response to organic substance
RNA splicing
second-messenger-mediated signaling - Gene Ontology Molecular Function:
- antigen binding
protein heterodimerization activity
protein phosphatase type 2A regulator activity
protein serine/threonine phosphatase activity - Gene Ontology Cellular Component:
- chromosome, centromeric region
cytosol
extracellular exosome
membrane
microtubule cytoskeleton
mitochondrion
nucleus
protein phosphatase type 2A complex - Keywords:
- 3D-structure
Acetylation
Centromere
Chromosome
Chromosome partition
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Mental retardation
Reference proteome
Repeat - Interacts With:
- P03081; P31749; P03129; P04020; Q8TCG1; P97346; P53816; P67775; P30154; P63151; Q00005; Q15172; Q13362; Q13362-1; Q13362-2; Q60996-3; Q14738; Q16537; P60510; P53041; Q04206; O43815; P04637