Names & Taxonomy

Uniprot ID:
P29973
Entry Name:
CNGA1_HUMAN
Status:
reviewed
Protein Names:
cGMP-gated cation channel alpha-1 (Cyclic nucleotide-gated cation channel 1) (Cyclic nucleotide-gated channel alpha-1) (CNG channel alpha-1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel, photoreceptor) (Rod photoreceptor cGMP-gated channel subunit alpha)
Gene Names:
CNGA1 CNCG CNCG1
Gene Names Primary:
CNGA1
Organism:
Homo sapiens (Human)

Structure

Length:
690
Sequence:
MKLSMKNNIINTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSASTSEESENENPHARGSFSYKSLRKGGPSQREQYLPGAIALFNVNNSSNKDQEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRLTKVEKFLKPLIDTEFSSIEGPGAESGPIDST
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Multi-pass membrane protein.

Function

Function:
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.
Gene Ontology Go:
integral component of plasma membrane
photoreceptor outer segment membrane
plasma membrane
cGMP binding
intracellular cAMP activated cation channel activity
intracellular cGMP activated cation channel activity
voltage-gated potassium channel activity
phototransduction, visible light
potassium ion transmembrane transport
regulation of membrane potential
regulation of rhodopsin mediated signaling pathway
rhodopsin mediated signaling pathway
transport
visual perception
Gene Ontology Biological Process:
phototransduction, visible light
potassium ion transmembrane transport
regulation of membrane potential
regulation of rhodopsin mediated signaling pathway
rhodopsin mediated signaling pathway
transport
visual perception
Gene Ontology Molecular Function:
cGMP binding
intracellular cAMP activated cation channel activity
intracellular cGMP activated cation channel activity
voltage-gated potassium channel activity
Gene Ontology Cellular Component:
integral component of plasma membrane
photoreceptor outer segment membrane
plasma membrane
Keywords:
Alternative splicing
Coiled coil
Complete proteome
Disease mutation
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Nucleotide-binding
Polymorphism
Reference proteome
Retinitis pigmentosa
Sensory transduction
Transmembrane
Transmembrane helix
Transport
Vision
cGMP
cGMP-binding
Interacts With:
Q5ICW4; Q9JLM9

Publication

PubMed ID:
1372902 1379636 14702039 15815621 7532814 7479749 15570217