Names & Taxonomy
- Uniprot ID:
- P29973
- Entry Name:
- CNGA1_HUMAN
- Status:
- reviewed
- Protein Names:
- cGMP-gated cation channel alpha-1 (Cyclic nucleotide-gated cation channel 1) (Cyclic nucleotide-gated channel alpha-1) (CNG channel alpha-1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel, photoreceptor) (Rod photoreceptor cGMP-gated channel subunit alpha)
- Gene Names:
- CNGA1 CNCG CNCG1
- Gene Names Primary:
- CNGA1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 690
- Sequence:
- MKLSMKNNIINTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSASTSEESENENPHARGSFSYKSLRKGGPSQREQYLPGAIALFNVNNSSNKDQEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRLTKVEKFLKPLIDTEFSSIEGPGAESGPIDST
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.
- Gene Ontology Go:
- integral component of plasma membrane
photoreceptor outer segment membrane
plasma membrane
cGMP binding
intracellular cAMP activated cation channel activity
intracellular cGMP activated cation channel activity
voltage-gated potassium channel activity
phototransduction, visible light
potassium ion transmembrane transport
regulation of membrane potential
regulation of rhodopsin mediated signaling pathway
rhodopsin mediated signaling pathway
transport
visual perception - Gene Ontology Biological Process:
- phototransduction, visible light
potassium ion transmembrane transport
regulation of membrane potential
regulation of rhodopsin mediated signaling pathway
rhodopsin mediated signaling pathway
transport
visual perception - Gene Ontology Molecular Function:
- cGMP binding
intracellular cAMP activated cation channel activity
intracellular cGMP activated cation channel activity
voltage-gated potassium channel activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
photoreceptor outer segment membrane
plasma membrane - Keywords:
- Alternative splicing
Coiled coil
Complete proteome
Disease mutation
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Nucleotide-binding
Polymorphism
Reference proteome
Retinitis pigmentosa
Sensory transduction
Transmembrane
Transmembrane helix
Transport
Vision
cGMP
cGMP-binding - Interacts With:
- Q5ICW4; Q9JLM9