Names & Taxonomy
- Uniprot ID:
- P29972
- Entry Name:
- AQP1_HUMAN
- Status:
- reviewed
- Protein Names:
- Aquaporin-1 (AQP-1) (Aquaporin-CHIP) (Urine water channel) (Water channel protein for red blood cells and kidney proximal tubule)
- Gene Names:
- AQP1 CHIP28
- Gene Names Primary:
- AQP1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 269
- Sequence:
- MASEFKKKLFWRAVVAEFLATTLFVFISIGSALGFKYPVGNNQTAVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISIFRALMYIIAQCVGAIVATAILSGITSSLTGNSLGRNDLADGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIYDFILAPRSSDLTDRVKVWTSGQVEEYDLDADDINSRVEMKPK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
- Intramembrane:
- INTRAMEM 71 76; INTRAMEM 77 84 Helical; Name=Helix B.; INTRAMEM 187 192; INTRAMEM 193 200 Helical; Name=Helix E.
Function
- Function:
- Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
- Cross Reference Drug Bank:
- DB00819
- Gene Ontology Go:
- apical part of cell
apical plasma membrane
basal plasma membrane
basolateral plasma membrane
brush border
brush border membrane
cytoplasm
extracellular exosome
integral component of plasma membrane
nuclear membrane
nucleus
plasma membrane
sarcolemma
symbiont-containing vacuole
ammonium transmembrane transporter activity
carbon dioxide transmembrane transporter activity
glycerol channel activity
glycerol transmembrane transporter activity
intracellular cGMP activated cation channel activity
nitric oxide transmembrane transporter activity
potassium channel activity
potassium ion transmembrane transporter activity
transmembrane transporter activity
water channel activity
water transmembrane transporter activity
ammonium transmembrane transport
ammonium transport
bicarbonate transport
carbon dioxide transmembrane transport
carbon dioxide transport
cation transmembrane transport
cell volume homeostasis
cellular homeostasis
cellular hyperosmotic response
cellular response to cAMP
cellular response to copper ion
cellular response to dexamethasone stimulus
cellular response to hydrogen peroxide
cellular response to hypoxia
cellular response to inorganic substance
cellular response to mechanical stimulus
cellular response to mercury ion
cellular response to nitric oxide
cellular response to retinoic acid
cellular response to salt stress
cellular response to stress
cellular response to UV
cerebrospinal fluid secretion
cGMP biosynthetic process
establishment or maintenance of actin cytoskeleton polarity
glycerol transport
lateral ventricle development
maintenance of symbiont-containing vacuole by host
multicellular organismal water homeostasis
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
nitric oxide transport
odontogenesis
pancreatic juice secretion
positive regulation of angiogenesis
positive regulation of fibroblast proliferation
positive regulation of saliva secretion
potassium ion transmembrane transport
potassium ion transport
renal water homeostasis
renal water transport
response to drug
small molecule metabolic process
transepithelial water transport
transmembrane transport
water transport - Gene Ontology Biological Process:
- ammonium transmembrane transport
ammonium transport
bicarbonate transport
carbon dioxide transmembrane transport
carbon dioxide transport
cation transmembrane transport
cellular homeostasis
cellular hyperosmotic response
cellular response to cAMP
cellular response to copper ion
cellular response to dexamethasone stimulus
cellular response to hydrogen peroxide
cellular response to hypoxia
cellular response to inorganic substance
cellular response to mechanical stimulus
cellular response to mercury ion
cellular response to nitric oxide
cellular response to retinoic acid
cellular response to salt stress
cellular response to stress
cellular response to UV
cell volume homeostasis
cerebrospinal fluid secretion
cGMP biosynthetic process
establishment or maintenance of actin cytoskeleton polarity
glycerol transport
lateral ventricle development
maintenance of symbiont-containing vacuole by host
multicellular organismal water homeostasis
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
nitric oxide transport
odontogenesis
pancreatic juice secretion
positive regulation of angiogenesis
positive regulation of fibroblast proliferation
positive regulation of saliva secretion
potassium ion transmembrane transport
potassium ion transport
renal water homeostasis
renal water transport
response to drug
small molecule metabolic process
transepithelial water transport
transmembrane transport
water transport - Gene Ontology Molecular Function:
- ammonium transmembrane transporter activity
carbon dioxide transmembrane transporter activity
glycerol channel activity
glycerol transmembrane transporter activity
intracellular cGMP activated cation channel activity
nitric oxide transmembrane transporter activity
potassium channel activity
potassium ion transmembrane transporter activity
transmembrane transporter activity
water channel activity
water transmembrane transporter activity - Gene Ontology Cellular Component:
- apical part of cell
apical plasma membrane
basal plasma membrane
basolateral plasma membrane
brush border
brush border membrane
cytoplasm
extracellular exosome
integral component of plasma membrane
nuclear membrane
nucleus
plasma membrane
sarcolemma
symbiont-containing vacuole - Keywords:
- 3D-structure
Alternative splicing
Blood group antigen
Cell membrane
Complete proteome
Direct protein sequencing
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport - Interacts With:
- Q96JN2-2; Q8IYA8; Q2TAC2; Q9C0F1; Q9NQ79; Q96S65; Q6FG41; A1L4K1; Q9UKS7; Q9UKT9; Q7L273; Q8N8K9; Q15323; Q14525; Q6A162; P60409; Q9BYR5; Q9BYQ4; Q99750; Q9UJV3-2; Q5JR59; Q7Z3S9; Q9UGC6; O76081; O76081-6; Q9UFD9; Q8IUQ4; O43597; P15884; Q07912; Q13077; Q12933; P36406; Q15654